ROCK2 |
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بنى متوفرة |
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بنك بيانات البروتين | Ortholog search: PDBe RCSB | قائمة رموز معرفات بنك بيانات البروتين | 4L6Q, 4WOT | | |
معرفات |
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أسماء بديلة | ROCK2, ROCK-II, Rho associated coiled-coil containing protein kinase 2 |
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معرفات خارجية | الوراثة المندلية البشرية عبر الإنترنت 604002 MGI: MGI:107926 HomoloGene: 21010 GeneCards: 9475 |
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علم الوجود الجيني |
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وظائف جزيئية | • نشاط انتقالي • nucleotide binding • protein kinase activity • structural molecule activity • ربط أيون فلزي • kinase activity • protein serine/threonine kinase activity • GO:0001948، GO:0016582 ربط بروتيني • ATP binding • Rho-dependent protein serine/threonine kinase activity • RNA binding • tau protein binding • tau-protein kinase activity |
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مكونات خلوية | • سيتوبلازم • جسيم مركزي • غشاء • غشاء خلوي • مركز تنظيم الأنيبيبات الدقيقة • حبيبة رنا • هيكل خلوي • نواة • عصارة خلوية • داخل خلوي |
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عمليات حيوية | • smooth muscle contraction • positive regulation of protein phosphorylation • GO:0007243 intracellular signal transduction • regulation of actin cytoskeleton organization • centrosome duplication • فسفرة • عملية إيقاعية • ephrin receptor signaling pathway • cellular response to testosterone stimulus • انقسام السيتوبلازم • positive regulation of centrosome duplication • regulation of stress fiber assembly • regulation of cell motility • positive regulation of endothelial cell migration • protein phosphorylation • negative regulation of bicellular tight junction assembly • vascular endothelial growth factor receptor signaling pathway • GO:1901313 positive regulation of gene expression • regulation of cell adhesion • regulation of circadian rhythm • Rho protein signal transduction • regulation of focal adhesion assembly • negative regulation of angiogenesis • regulation of keratinocyte differentiation • negative regulation of myosin-light-chain-phosphatase activity • I-kappaB kinase/NF-kappaB signaling • regulation of establishment of cell polarity • GO:0033109 cortical actin cytoskeleton organization • regulation of establishment of endothelial barrier • actin cytoskeleton organization • protein localization to plasma membrane • G protein-coupled receptor signaling pathway • aortic valve morphogenesis • positive regulation of cardiac muscle hypertrophy • GO:0035404 peptidyl-serine phosphorylation • peptidyl-threonine phosphorylation • positive regulation of cell migration • positive regulation of connective tissue growth factor production • positive regulation of MAPK cascade • regulation of protein metabolic process • positive regulation of stress fiber assembly • negative regulation of biomineral tissue development • response to transforming growth factor beta • positive regulation of fibroblast growth factor production • regulation of angiotensin-activated signaling pathway • negative regulation of protein localization to lysosome • positive regulation of amyloid-beta formation • positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process • positive regulation of protein localization to early endosome • positive regulation of amyloid precursor protein catabolic process • positive regulation of connective tissue replacement • response to angiotensin • response to ischemia • negative regulation of gene expression • regulation of nervous system process • negative regulation of nitric oxide biosynthetic process • mRNA destabilization • blood vessel diameter maintenance • regulation of cellular response to hypoxia • cellular response to acetylcholine • mitotic cytokinesis • actomyosin structure organization • embryonic morphogenesis • regulation of cell junction assembly |
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المصادر:Amigo / QuickGO | |
تماثلات متسلسلة |
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أنواع | الإنسان | الفأر |
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أنتريه | 9475 | 19878 |
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Ensembl | ENSG00000134318 | ENSMUSG00000020580 |
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يونيبروت | | |
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RefSeq (رنا مرسال.) | | NM_004850، XM_005246190، NM_001321643، XM_017005378، XM_017005379 XM_011510417، NM_004850، XM_005246190، NM_001321643، XM_017005378، XM_017005379 |
| | XM_006515019، XM_006515020 NM_009072، XM_006515019، XM_006515020 |
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RefSeq (بروتين) | | NP_004841، XP_005246247، XP_011508719، XP_016860867، XP_016860868 NP_001308572، NP_004841، XP_005246247، XP_011508719، XP_016860867، XP_016860868 |
| | XP_036013163، XP_036013164، XP_036013165، XP_036013166، XP_036013167، XP_036013168 NP_033098، XP_036013163، XP_036013164، XP_036013165، XP_036013166، XP_036013167، XP_036013168 |
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الموقع (UCSC | n/a | Chr 12: 16.89 – 16.99 Mb |
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بحث ببمد | [1] | [2] |
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ويكي بيانات |
اعرض/عدّل إنسان | اعرض/عدّل فأر |
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