周期蛋白D1

周期蛋白D1
Rendering based on PDB 2W96.
有效结构
PDB 直系同源检索：PDBe, RCSB
PDB查询代码列表

2W96, 2W99, 2W9F, 2W9Z

标识
代号 CCND1; BCL1; D11S287E; PRAD1; U21B31
扩展标识 遗传学：168461 鼠基因：88313 同源基因：1334 ChEMBL: 3610 GeneCards: CCND1 Gene
基因本体论描述
分子功能 · protein kinase activity

· protein binding
· cyclin-dependent protein serine/threonine kinase regulator activity
· enzyme binding
· protein kinase binding

· protein complex binding
细胞成分 · cyclin-dependent protein kinase holoenzyme complex

· intracellular
· nucleus
· nucleoplasm
· cytosol
· tight junction

· membrane
生物过程 · G1 phase of mitotic cell cycle

· G1/S transition of mitotic cell cycle
· S phase of mitotic cell cycle
· mitotic cell cycle
· re-entry into mitotic cell cycle
· liver development
· positive regulation of protein phosphorylation
· response to DNA damage stimulus
· lactation
· response to iron ion
· response to X-ray
· response to organic nitrogen
· negative regulation of Wnt receptor signaling pathway
· negative regulation of epithelial cell differentiation
· endoplasmic reticulum unfolded protein response
· organ regeneration
· mitotic G1 DNA damage checkpoint
· response to magnesium ion
· response to vitamin E
· Leydig cell differentiation
· mammary gland epithelial cell proliferation
· positive regulation of mammary gland epithelial cell proliferation
· response to drug
· response to estrogen stimulus
· fat cell differentiation
· response to ethanol
· positive regulation of cyclin-dependent protein kinase activity
· cell division
· response to corticosterone stimulus
· response to calcium ion
· canonical Wnt receptor signaling pathway
· mammary gland alveolus development
· response to UV-A

· regulation of G1/S transition of mitotic cell cycle
Sources: Amigo / QuickGO
RNA表达模式
更多表达数据
直系同源体
物种 人类 小鼠
Entrez 595 12443
Ensembl ENSG00000110092 ENSMUSG00000070348
UniProt P24385 P25322
mRNA序列 NM_053056 NM_007631
蛋白序列 NP_444284 NP_031657
基因位置 Chr 11:
69.46 – 69.47 Mb		 Chr 7:
144.93 – 144.94 Mb
PubMed查询 [1] [2]
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G1/S-特异性周期蛋白-D1是一个由人类CCND1基因所编码的蛋白质[1][2]。

该基因编码的蛋白质属于高度保守的周期蛋白家族，该家族成员的显著特征是贯穿细胞周期，其蛋白质丰度周期性地急剧改变。周期蛋白作为CDK（周期蛋白依赖性激酶）的调节因子。不同的周期蛋白表现出各自独特的表达及降解特性，这有助于每个有丝分裂事件在时间上的协调性。周期蛋白D1这种亚型的周期蛋白与CDK4或CDK6形成复合物并作为它们的调节亚基，这两种周期蛋白依赖性激酶对于G1到S期的转变来说是不可或缺的。该蛋白表现出与抑癌基因Rb有着相互作用，且此基因的表达受Rb的正向调控。周期蛋白D1发生突变、扩增及过表达将会改变细胞周期进程，这些现象常发生在多种肿瘤中并可能导致肿瘤发生[3]。

套细胞淋巴瘤中对周期蛋白D1进行染色的显微图

使用周期蛋白D1进行免疫组化染色可用于诊断套细胞淋巴瘤。

另见

  • 甲状旁腺腺瘤
  • 套细胞淋巴瘤

参考文献

  1. ^ Motokura T, Bloom T, Kim HG, Juppner H, Ruderman JV, Kronenberg HM, Arnold A. A novel cyclin encoded by a bcl1-linked candidate oncogene. Nature. May 1991, 350 (6318): 512–5. PMID 1826542. doi:10.1038/350512a0. 
  2. ^ Lew DJ, Dulic V, Reed SI. Isolation of three novel human cyclins by rescue of G1 cyclin (Cln) function in yeast. Cell. October 1991, 66 (6): 1197–206. PMID 1833066. doi:10.1016/0092-8674(91)90042-W. 
  3. ^ Entrez Gene: CCND1 cyclin D1. （原始内容存档于2009-05-11）. 

深入阅读

  • Akita H. [Prognostic importance of altered expression of cell cycle regulators in lung cancer]. Nippon Rinsho. 2003,. 60 Suppl 5: 267–71. PMID 12101670. 
  • Chung DC. Cyclin D1 in human neuroendocrine: tumorigenesis. Ann. N. Y. Acad. Sci. 2004, 1014: 209–17. PMID 15153436. doi:10.1196/annals.1294.022. 
  • Jain S, Khuri FR, Shin DM. Prevention of head and neck cancer: current status and future prospects. Current Problems in Cancer. 2004, 28 (5): 265–86. PMID 15375804. doi:10.1016/j.currproblcancer.2004.05.003. 
  • Gladden AB, Diehl JA. Location, location, location: the role of cyclin D1 nuclear localization in cancer. J. Cell. Biochem. 2006, 96 (5): 906–13. PMID 16163738. doi:10.1002/jcb.20613. 
  • Walker JL, Assoian RK. Integrin-dependent signal transduction regulating cyclin D1 expression and G1 phase cell cycle progression. Cancer Metastasis Rev. 2006, 24 (3): 383–93. PMID 16258726. doi:10.1007/s10555-005-5130-7. 
  • Gautschi O, Ratschiller D, Gugger M; et al. Cyclin D1 in non-small cell lung cancer: a key driver of malignant transformation. Lung Cancer. 2007, 55 (1): 1–14. PMID 17070615. doi:10.1016/j.lungcan.2006.09.024.  引文格式1维护：显式使用等标签 (link)
  • Li Z, Wang C, Prendergast GC, Pestell RG. Cyclin D1 functions in cell migration. Cell Cycle. 2007, 5 (21): 2440–2. PMID 17106256. 
  • Tao Zhang, Breslin MB, Lan MS. Zinc Finger Transcription Factor INSM1 Interrupts Cyclin D1 and CDK4 Binding and Induces Cell Cycle Arrest. J. Biol. Chem. 2009, 284 (9): 5574–81. PMC 2645817 可免费查阅. PMID 19124461. doi:10.1074/jbc.M808843200. 
  • Inaba T, Matsushime H, Valentine M; et al. Genomic organization, chromosomal localization, and independent expression of human cyclin D genes. Genomics. 1992, 13 (3): 565–74. PMID 1386335. doi:10.1016/0888-7543(92)90126-D.  引文格式1维护：显式使用等标签 (link)
  • Schuuring E, Verhoeven E, Mooi WJ, Michalides RJ. Identification and cloning of two overexpressed genes, U21B31/PRAD1 and EMS1, within the amplified chromosome 11q13 region in human carcinomas. Oncogene. 1992, 7 (2): 355–61. PMID 1532244. 
  • Seto M, Yamamoto K, Iida S; et al. Gene rearrangement and overexpression of PRAD1 in lymphoid malignancy with t(11;14)(q13;q32) translocation. Oncogene. 1992, 7 (7): 1401–6. PMID 1535701.  引文格式1维护：显式使用等标签 (link)
  • Rosenberg CL, Wong E, Petty EM; et al. PRAD1, a candidate BCL1 oncogene: mapping and expression in centrocytic lymphoma. Proc. Natl. Acad. Sci. U.S.A. 1991, 88 (21): 9638–42. PMC 52773 可免费查阅. PMID 1682919. doi:10.1073/pnas.88.21.9638.  引文格式1维护：显式使用等标签 (link)
  • Xiong Y, Connolly T, Futcher B, Beach D. Human D-type cyclin. Cell. 1991, 65 (4): 691–9. PMID 1827756. doi:10.1016/0092-8674(91)90100-D. 
  • Withers DA, Harvey RC, Faust JB; et al. Characterization of a candidate bcl-1 gene. Mol. Cell. Biol. 1991, 11 (10): 4846–53. PMC 361453 可免费查阅. PMID 1833629.  引文格式1维护：显式使用等标签 (link)
  • Tsujimoto Y, Yunis J, Onorato-Showe L; et al. Molecular cloning of the chromosomal breakpoint of B-cell lymphomas and leukemias with the t(11;14) chromosome translocation. Science. 1984, 224 (4656): 1403–6. PMID 6610211. doi:10.1126/science.6610211.  引文格式1维护：显式使用等标签 (link)
  • Hall M, Bates S, Peters G. Evidence for different modes of action of cyclin-dependent kinase inhibitors: p15 and p16 bind to kinases, p21 and p27 bind to cyclins. Oncogene. 1995, 11 (8): 1581–8. PMID 7478582. 
  • Tassan JP, Jaquenoud M, Léopold P; et al. Identification of human cyclin-dependent kinase 8, a putative protein kinase partner for cyclin C. Proc. Natl. Acad. Sci. U.S.A. 1995, 92 (19): 8871–5. PMC 41069 可免费查阅. PMID 7568034. doi:10.1073/pnas.92.19.8871.  引文格式1维护：显式使用等标签 (link)
  • Fornaro M, Dell'Arciprete R, Stella M; et al. Cloning of the gene encoding Trop-2, a cell-surface glycoprotein expressed by human carcinomas. Int. J. Cancer. 1995, 62 (5): 610–8. PMID 7665234. doi:10.1002/ijc.2910620520.  引文格式1维护：显式使用等标签 (link)
  • Motokura T, Arnold A. PRAD1/cyclin D1 proto-oncogene: genomic organization, 5' DNA sequence, and sequence of a tumor-specific rearrangement breakpoint. Genes Chromosomes Cancer. 1993, 7 (2): 89–95. PMID 7687458. doi:10.1002/gcc.2870070205. 



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週期素
  • A（A1、A2）
  • B（B1、B2、B3）
  • D（D1、D2、D3）
  • E（E1、E2）
细胞周期示意图
CDK
  • 1
  • 2
  • 3
  • 4
  • 5
  • 6
  • 7
  • z
  • 9
  • 10
  • 周期蛋白依赖性激酶激活激酶（英语：CDK-activating kinase）
CDK抑制因子（英语：Cyclin-dependent kinase inhibitor protein）
P53 p63 p73家族
其他
  • Cdc2
  • Cdc25（英语：Cdc25）
  • Cdc42（英语：CDC42）
  • 细胞凋亡易感蛋白（英语：Cellular apoptosis susceptibility protein）
  • E2F
  • 促成熟因子（英语：Maturation promoting factor）
  • Wee
  • Cullin
    • CUL7
期与
检查点
間期
M期
  • 有絲分裂
    • 早前期
    • 前期
    • 前中期（英语：Prometaphase）
    • 中期（英语：Metaphase）
    • 后期（英语：Anaphase）
    • 末期（英语：Telophase）
  • 胞质分裂（英语：Cytokinesis）
細胞週期檢查點
  • 限制点（英语：Restriction point）
  • 纺锤体检查点（英语：Spindle checkpoint）
  • 复制后检查点（英语：Postreplication checkpoint）
其他细胞期
参见：蛋白质生物合成导航