UGT1A5

Identifikatori

Alijasi

UGT1A5

Spoljašnji ID

OMIM: 606430 HomoloGene: 117984 GeneCards: UGT1A5

Genska ontologija
Molecular function	• glycosyltransferase activity • transferase activity • glucuronosyltransferase activity • hexosyltransferase activity • UDP-glycosyltransferase activity
Cellular component	• саставни део мембране • мембрана • ендоплазматични ретикулум • endoplasmic reticulum membrane • intracellular membrane-bounded organelle
Biological process	• метаболизам • xenobiotic glucuronidation • flavonoid glucuronidation
Sources:Amigo / QuickGO

Ortolozi

Vrste

Čovek

Miš

Entrez


54579


n/a

Ensembl


ENSG00000288705


n/a

UniProt


P35504


n/a

RefSeq (mRNA)


NM_019078


n/a

RefSeq (protein)


NP_061951


n/a

Location (UCSC)

n/a

PubMed search

^[1]

n/a

Wikidata

View/Edit Human

UDP-glukuronoziltransferaza 1-5 je enzim koji je kod ljudi kodiran genom UGT1A5.^[2]^[3]^[4]

Reference

^ „Human PubMed Reference:”. National Center for Biotechnology Information, U.S. National Library of Medicine.
^ „Entrez Gene: UDP glucuronosyltransferase 1 family”.
^ Ritter JK, Chen F, Sheen YY, Tran HM, Kimura S, Yeatman MT, Owens IS (фебруар 1992). „A novel complex locus UGT1 encodes human bilirubin, phenol, and other UDP-glucuronosyltransferase isozymes with identical carboxyl termini”. J. Biol. Chem. 267 (5): 3257—61. PMID 1339448. doi:10.1016/S0021-9258(19)50724-4 . CS1 одржавање: Формат датума (веза)
^ Mackenzie PI, Owens IS, Burchell B, Bock KW, Bairoch A, Bélanger A, Fournel-Gigleux S, Green M, Hum DW, Iyanagi T, Lancet D, Louisot P, Magdalou J, Chowdhury JR, Ritter JK, Schachter H, Tephly TR, Tipton KF, Nebert DW (август 1997). „The UDP glycosyltransferase gene superfamily: recommended nomenclature update based on evolutionary divergence”. Pharmacogenetics. 7 (4): 255—69. PMID 9295054. doi:10.1097/00008571-199708000-00001. CS1 одржавање: Формат датума (веза)

Literatura

Yea SS, Lee SS, Kim WY, et al. (2008). „Genetic variations and haplotypes of UDP-glucuronosyltransferase 1A locus in a Korean population.”. Ther Drug Monit. 30 (1): 23—34. PMID 18223459. S2CID 34396409. doi:10.1097/FTD.0b013e3181633824.
Sanna S, Busonero F, Maschio A, et al. (2009). „Common variants in the SLCO1B3 locus are associated with bilirubin levels and unconjugated hyperbilirubinemia”. Hum. Mol. Genet. 18 (14): 2711—8. PMC 2701337 . PMID 19419973. doi:10.1093/hmg/ddp203.
Zhang T, Haws P, Wu Q (2004). „Multiple Variable First Exons: A Mechanism for Cell- and Tissue-Specific Gene Regulation”. Genome Res. 14 (1): 79—89. PMC 314283 . PMID 14672974. doi:10.1101/gr.1225204.
King CD, Rios GR, Green MD, Tephly TR (2000). „UDP-glucuronosyltransferases”. Curr. Drug Metab. 1 (2): 143—61. PMID 11465080. doi:10.2174/1389200003339171.
van Es HH, Bout A, Liu J, et al. (1993). „Assignment of the human UDP glucuronosyltransferase gene (UGT1A1) to chromosome region 2q37”. Cytogenet. Cell Genet. 63 (2): 114—6. PMID 8467709. doi:10.1159/000133513.
Gong QH, Cho JW, Huang T, et al. (2001). „Thirteen UDPglucuronosyltransferase genes are encoded at the human UGT1 gene complex locus”. Pharmacogenetics. 11 (4): 357—68. PMID 11434514. doi:10.1097/00008571-200106000-00011.
Tukey RH, Strassburg CP (2000). „Human UDP-glucuronosyltransferases: metabolism, expression, and disease”. Annu. Rev. Pharmacol. Toxicol. 40: 581—616. PMID 10836148. doi:10.1146/annurev.pharmtox.40.1.581.
Ross CJ, Katzov-Eckert H, Dubé MP, et al. (2009). „Genetic variants in TPMT and COMT are associated with hearing loss in children receiving cisplatin chemotherapy”. Nat. Genet. 41 (12): 1345—9. PMID 19898482. S2CID 21293339. doi:10.1038/ng.478.
Johnson AD, Kavousi M, Smith AV, Chen MH, Dehghan A, Aspelund T, Lin JP, van Duijn CM, Harris TB, Cupples LA, Uitterlinden AG, Launer L, Hofman A, Rivadeneira F, Stricker B, Yang Q, O'Donnell CJ, Gudnason V, Witteman JC (јул 2009). „Genome-wide association meta-analysis for total serum bilirubin levels”. Hum. Mol. Genet. 18 (14): 2700—10. PMC 2701336 . PMID 19414484. doi:10.1093/hmg/ddp202. CS1 одржавање: Формат датума (веза)

Transferaze: glikoziltransferaze (EC 2.4)

2.4.1: Heksozil-
transferaze

Glukozil-	Fosforilaza Skrob Glikogen Mio- Glikogenska sintaza Enzim razgradnje glikogenskih grana Enzim glikogenskog grananja 1,3-Beta-glukan sintaza Keramidna glukoziltransferaza
Galaktozil-	Laktozna sintaza B-N-acetilglukozaminil-glikopeptid b-1,4-galaktoziltransferaza Glikoprotein-N-acetilgalaktozamin 3-b-galaktoziltransferaza (C1GALT1)
Glukuronozil-	B3GAT1 B3GAT2 B3GAT3 UGT1A1 UGT1A3 UGT1A4 UGT1A5 UGT1A6 UGT1A7 UGT1A8 UGT1A9 UGT1A10 UGT2A1 UGT2A2 UGT2A3 UGT2B4 UGT2B7 UGT2B10 UGT2B11 UGT2B15 UGT2B17 UGT2B28 Hijaluronan sintaza: HAS1 HAS2 HAS3
Fukozil-	POFUT1 POFUT2 FUT1 FUT2 FUT3 FUT4 FUT5 FUT6 FUT7 FUT8 FUT9 FUT10 FUT11
Manozil-	Dolihil-fosfat-manoza-protein manoziltransferaza POMT1 POMT2 DPM1 DPM3 ALG1 ALG2 ALG3 ALG6 ALG8 ALG9 ALG12

2.4.2: Pentozil-
transferaze

Riboza

ADP-riboziltransferaza	NAD⁺:diftamid ADP-riboziltransferaza Toksin difterije NAD(P)⁺:arginin ADP-riboziltransferaza Pertuzijski toksin Toksin kolere NAD+ ADP-riboziltransferaza Sirtuin
Fosforiboziltransferaza	Adenin fosforiboziltransferaza Hipoksantin fosforiboziltransferaza Uracil fosforiboziltransferaza Amidofosforiboziltransferaza
Drugi	Purin-nukleozid fosforilaza: Timidinska fosforilaza ECGF1