P2RY14

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Purinski receptor P2Y, G-protein spregnuti, 14
Identifikatori
SimboliP2RY14; GPR105; KIAA0001; P2Y14
Vanjski IDOMIM: 610116 MGI: 2155705 HomoloGene: 15769 IUPHAR: P2Y14 GeneCards: P2RY14 Gene
Ontologija gena
Molekularna funkcija • aktivnost rodopsinu-sličnog receptora
• receptorska aktivnost
• aktivnost purinskog nukleotidnog receptora, G-protein spregnutog
• aktivnost UDP-aktiviranog nukleotidnog receptora
Celularna komponenta • membrana
• integralno sa membranom
Biološki proces • prenos signala
• signalni put G-protein spregnutog receptora
Pregled RNK izražavanja
podaci
Ortolozi
VrstaČovekMiš
Entrez9934140795
EnsemblENSG00000174944ENSMUSG00000036381
UniProtQ15391Q544F4
RefSeq (mRNA)NM_001081455NM_001008497
RefSeq (protein)NP_001074924NP_001008497
Lokacija (UCSC)Chr 3:
152.41 - 152.48 Mb		Chr 3:
59.2 - 59.22 Mb
PubMed pretraga[1][2]

P2Y purinoceptor 14 je protein koji je kod ljudi kodiran P2RY14 genom.[1]

Proizvod P2RY14 gena pripada familiji G-protein spregnutih receptora. Postoji nekoliko tipova receptora sa različitom farmakološkom selektivnošću za razne adenozinske i uridinske nukleotide. Ovaj receptor je P2Y purinski receptor za UDP-glukozu i druge UDP-šećere spregnute sa G-proteinima. Smatra se da on učestvuje u dejstvu imunskog sistema putem regulacije matičnih ćelija, kao i u neuroimunskim funkcijama. Dve transkriptne varijante koje kodiraju isti protein su poznate.[1]

Vidi još

Reference

  1. ↑ 1,0 1,1 „Entrez Gene: P2RY14 purinergic receptor P2Y, G-protein coupled, 14”. 

Literatura

  • Gerard C, Gerard NP (1994). „C5A anaphylatoxin and its seven transmembrane-segment receptor.”. Annu. Rev. Immunol. 12: 775–808. DOI:10.1146/annurev.iy.12.040194.004015. PMID 8011297. 
  • Müller CE (2003). „P2-pyrimidinergic receptors and their ligands.”. Curr. Pharm. Des. 8 (26): 2353–69. DOI:10.2174/1381612023392937. PMID 12369950. 
  • Abbracchio MP, Boeynaems JM, Barnard EA, et al. (2003). „Characterization of the UDP-glucose receptor (re-named here the P2Y14 receptor) adds diversity to the P2Y receptor family.”. Trends Pharmacol. Sci. 24 (2): 52–5. DOI:10.1016/S0165-6147(02)00038-X. PMID 12559763. 
  • von Kügelgen I (2006). „Pharmacological profiles of cloned mammalian P2Y-receptor subtypes.”. Pharmacol. Ther. 110 (3): 415–32. DOI:10.1016/j.pharmthera.2005.08.014. PMID 16257449. 
  • Brunschweiger A, Müller CE (2006). „P2 receptors activated by uracil nucleotides--an update.”. Curr. Med. Chem. 13 (3): 289–312. DOI:10.2174/092986706775476052. PMID 16475938. 
  • Nomura N, Miyajima N, Sazuka T, et al. (1995). „Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1.”. DNA Res. 1 (1): 27–35. DOI:10.1093/dnares/1.1.27. PMID 7584026. 
  • Nomura N, Miyajima N, Sazuka T, et al. (1995). „Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1 (supplement).”. DNA Res. 1 (1): 47–56. DOI:10.1093/dnares/1.1.47. PMID 7584028. 
  • Charlton ME, Williams AS, Fogliano M, et al. (1997). „The isolation and characterization of a novel G protein-coupled receptor regulated by immunologic challenge.”. Brain Res. 764 (1-2): 141–8. DOI:10.1016/S0006-8993(97)00438-1. PMID 9295203. 
  • Joensuu T, Hämäläinen R, Lehesjoki AE, et al. (2000). „A sequence-ready map of the Usher syndrome type III critical region on chromosome 3q.”. Genomics 63 (3): 409–16. DOI:10.1006/geno.1999.6096. PMID 10704288. 
  • Chambers JK, Macdonald LE, Sarau HM, et al. (2000). „A G protein-coupled receptor for UDP-glucose.”. J. Biol. Chem. 275 (15): 10767–71. DOI:10.1074/jbc.275.15.10767. PMID 10753868. 
  • Wittenberger T, Schaller HC, Hellebrand S (2001). „An expressed sequence tag (EST) data mining strategy succeeding in the discovery of new G-protein coupled receptors.”. J. Mol. Biol. 307 (3): 799–813. DOI:10.1006/jmbi.2001.4520. PMID 11273702. 
  • Joensuu T, Hämäläinen R, Yuan B, et al. (2001). „Mutations in a novel gene with transmembrane domains underlie Usher syndrome type 3.”. Am. J. Hum. Genet. 69 (4): 673–84. DOI:10.1086/323610. PMC 1226054. PMID 11524702. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). „Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.”. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. DOI:10.1073/pnas.242603899. PMC 139241. PMID 12477932. 
  • Lazarowski ER, Shea DA, Boucher RC, Harden TK (2003). „Release of cellular UDP-glucose as a potential extracellular signaling molecule.”. Mol. Pharmacol. 63 (5): 1190–7. DOI:10.1124/mol.63.5.1190. PMID 12695547. 
  • Lee BC, Cheng T, Adams GB, et al. (2003). „P2Y-like receptor, GPR105 (P2Y14), identifies and mediates chemotaxis of bone-marrow hematopoietic stem cells.”. Genes Dev. 17 (13): 1592–604. DOI:10.1101/gad.1071503. PMC 196132. PMID 12842911. 
  • Skelton L, Cooper M, Murphy M, Platt A (2003). „Human immature monocyte-derived dendritic cells express the G protein-coupled receptor GPR105 (KIAA0001, P2Y14) and increase intracellular calcium in response to its agonist, uridine diphosphoglucose.”. J. Immunol. 171 (4): 1941–9. PMID 12902497. 
  • Moore DJ, Murdock PR, Watson JM, et al. (2004). „GPR105, a novel Gi/o-coupled UDP-glucose receptor expressed on brain glia and peripheral immune cells, is regulated by immunologic challenge: possible role in neuroimmune function.”. Brain Res. Mol. Brain Res. 118 (1-2): 10–23. DOI:10.1016/S0169-328X(03)00330-9. PMID 14559350. 

Spoljašnje veze

  • „P2Y Receptors: P2Y14”. IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. Arhivirano iz originala na datum 2016-03-03. 
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Klasa A: Rodopsinu slični
α1 (A, B, D) • α2 (A, B, C) • β1 • β2 • β3
Adenozinski (A1, A2A, A2B, A3) • P2Y (1, 2, 4, 5, 6, 8, 9, 10, 11, 12, 13, 14)
(svi osim 5-HT3) 5-HT1 (A, B, D, E, F) • 5-HT2 (A, B, C) • 5-HT (4, 5A, 6, 7)
Drugi
Acetilholin (M1, M2, M3, M4, M5) • Dopamin (D1, D2, D3, D4, D5) • Histamin (H1, H2, H3, H4) • Melatonin (1A, 1B, 1C) • TAAR (1, 2, 3, 5, 6, 8, 9)
Metaboliti i
signalni molekuli
CysLT (1, 2) • LTB4 (1, 2) • FPRL1 • OXE • Prostaglandin (DP (1, 2), EP (1, 2, 3, 4), FP) • Prostaciklin • Tromboksan
Drugi
Žučna kiselina • Kanabinoidni (CB1, CB2, GPR (18, 55, 119)) • EBI2 • Estrogen • Slobodna masna kiselina (1, 2, 3, 4) • Laktat  • Lizofosfatidna kiselina (1, 2, 3, 4, 5, 6)  • Lizofosfolipid (1, 2, 3, 4, 5, 6, 7, 8) • Niacin (1, 2) • Oksoglutarat • PAF • Sfingozin-1-fosfat (1, 2, 3, 4, 5) • Sukcinat
Peptid
B/W (1, 2) • FF (1, 2) • S • Y (1, 2, 4, 5) • Neuromedin (B, U (1, 2)) • Neurotenzin (1, 2)
Drugi
Anafilatoksin (C3a, C5a) • Angiotenzin (1, 2) • Apelin • Bombezin (BRS3, GRPR, NMBR) • Bradikinin (B1, B2) • Hemokin • Holecistokinin (A, B) • Endotelin (A, B) • Formil peptid (1, 2, 3) • FSH • Galanin (1, 2, 3) • GHB receptor • Gonadotropin-oslobađajući hormon (1, 2) • Grelin • Kispeptin • Luteinizirajući hormon/horiogonadotropin • MAS (1, 1L, D, E, F, G, X1, X2, X3, X4) • Melanokortin (1, 2, 3, 4, 5) • MCHR (1, 2) • Motilin • Opioidni (δ, κ, μ, Nociceptin & ζ, ali ne σ) • Oreksin (1, 2) • Oksitocin • Prokineticin (1, 2) • Prolaktin-oslobađajući peptid • Relaksin (1, 2, 3, 4) • Somatostatin (1, 2, 3, 4, 5) • Tahikinin (1, 2, 3) • Tirotropin • Tirotropin-oslobađajući hormon • Urotenzin-II • Vazopresin (1A, 1B, 2)
Razno
GPR (1, 3, 4, 6, 12, 15, 17, 18, 19, 20, 21, 22, 23, 25, 26, 27, 31, 32, 33, 34, 35, 37, 39, 42, 44, 45, 50, 52, 55, 61, 62, 63, 65, 68, 75, 77, 78, 81, 82, 83, 84, 85, 87, 88, 92, 101, 103, 109A, 109B, 119, 120, 132, 135, 137B, 139, 141, 142, 146, 148, 149, 150, 151, 152, 153, 160, 161, 162, 171, 173, 174, 176, 177, 182, 183)
Drugi
Adrenomedulin • Mirisni • Opsin (3, 4, 5, 1LW, 1MW, 1SW, RGR, RRH) • Proteazom-aktivirani (1, 2, 3, 4) • SREB (1, 2, 3)
Klasa B: Sekretinu slični
GPR (56, 64, 97, 98, 110, 111, 112, 113, 114, 115, 116, 123, 124, 125, 126, 128, 133, 143, 144, 155, 157)
Drugi
Klasa C: Metabotropni
glutamat / feromon
TAS1R (1, 2, 3) • TAS2R (1, 3, 4, 5, 8, 9, 10, 12, 13, 14, 16, 19, 20, 30, 31, 38, 39, 40, 41, 42, 43, 45, 46, 50)
Drugi
Klasa F:
Frizzled / Zaglađeni
Uvojiti
Frizzled (1, 2, 3, 4, 5, 6, 7, 8, 9, 10)
Zaglađeni
B trdu: peptidi (nrpl/grfl/cytl/horl), receptori (lgic, enzr, gprc, igsr, intg, nrpr/grfr/cytr), itra (adap, gbpr, mapk), calc, lipd, signalni putevi (hedp, wntp, tgfp+mapp, notp, jakp, fsap, hipp, tlrp)