Moždani natriuretski peptid

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Natriuretski peptid B
Dostupne strukture
1YK1, 3N56
Identifikatori
SimboliNPPB; BNP
Vanjski IDOMIM: 600295 HomoloGene: 81698 GeneCards: NPPB Gene
Ontologija gena
Molekularna funkcija • receptorsko vezivanje
• hormonska aktivnost
• aktivnost diuretiskog hormona
Celularna komponenta • ekstracelularni region
• ekstracelularni prostor
• nukleus
Biološki proces • response to hipoksiju
• cGMP biosintetički proces
• inflamatorni respons
Pregled RNK izražavanja
podaci
Ortolozi
VrstaČovekMiš
Entrez4879n/a
EnsemblENSG00000120937n/a
UniProtP16860n/a
RefSeq (mRNA)NM_002521.2n/a
RefSeq (protein)NP_002512.1n/a
Lokacija (UCSC)Chr 1:
11.92 - 11.92 Mb		n/a
PubMed pretraga[1]n/a

Moždani natriuretski peptid (osnovni natriuretski peptid, B-tip natriuretskog peptida, BNP, GC-B) je 32 aminokiseline dug polipeptid koji izlučuju srčane komore u odgovoru na prekomerno istezanje ćelija srčanog mišića (kardiomioccta). Oslobađanje BNP-a je modulisano jonima kalcijuma.[1] BNP se naziva moždanim peptidom jer je originalno ekstrahovan iz svinjskog mozga. Kod ljud ovaj hormon uglavnom proizvode srčane komore.

BNP se izlučuje zajedno sa 76 aminokiselina dugim N-terminalnim fragmentom (NT-proBNP) koji je biološki neaktivan. BNP se vezuje za i aktivira receptore atrijalnog natriuretskog faktora receptors NPRA, i manjoj meri NPRB, na sličan način kao i atrijalni natriuretski peptid (ANP) ali sa 10 puta manjim afinitetom. Biološki poluživot BNP-a je dva puta duži ANP, dok je poluživot NT-proBNP peptida još duži. It tog razloga ti peptidi su bolja meta za dijagnostičko testiranje krvi

Reference

  1. ↑ Ziskoven D, Forssmann WG, Holthausen U, Menz G, Addicks K, Rippegater G: Calcium Calmodulinantagonists Influences the release of Cardiodilatin/ANP from Atrial Cardiocytes. Handbook Endocrinology of the Heart, edited by Kaufmann W, Wambach G, 01/1989; Springer Verlag Berlin Heidelberg New York; ISBN/EAN 978-3-540-51409-1

Literatura

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Spoljašnje veze

  • MeSH Brain+Natriuretic+Peptide
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Endokrine
žlezde
Hipotalamusno-
hipofizni
Druge endokrine
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Neendokrine
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M: END

anat/phys/devp/horm/cell

noco(d)/cong/tumr, sysi/epon

proc, lek (A10/H1/H2/H3/H5)