Alaninska aminopeptidaza
| Alaninska aminopeptidaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 3.4.11.2 | ||||||||
| CAS broj | 9054-63-1 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
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| edit |
| Alaninska aminopeptidaza | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Dostupne strukture | |||||||||||
| 4FYQ, 4FYR, 4FYS, 4FYT | |||||||||||
| Identifikatori | |||||||||||
| Simboli | ANPEP; APN; CD13; GP150; LAP1; P150; PEPN | ||||||||||
| Vanjski ID | OMIM: 151530 MGI: 96749 HomoloGene: 68163 GeneCards: ANPEP Gene | ||||||||||
| EC broj | 3.4.11.2 | ||||||||||
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| Pregled RNK izražavanja | |||||||||||
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| podaci | |||||||||||
| Ortolozi | |||||||||||
| Vrsta | Čovek | Miš | |||||||||
| Entrez | 290 | 16790 | |||||||||
| Ensembl | ENSG00000166825 | ENSMUSG00000039062 | |||||||||
| UniProt | P15144 | P97449 | |||||||||
| RefSeq (mRNA) | NM_001150.2 | NM_008486.2 | |||||||||
| RefSeq (protein) | NP_001141.2 | NP_032512.2 | |||||||||
| Lokacija (UCSC) | Chr 15: 90.33 - 90.36 Mb | Chr 7: 79.82 - 79.85 Mb | |||||||||
| PubMed pretraga | [1] | [2] | |||||||||
Alaninska aminopeptidaza (EC 3.4.11.2) je enzim koji se koristi kao biomarker za detekciju oštećenja bubrega. On se može koristiti u dijagnozi pojedinih tipova bubrežnih poremećaja. Ona je prisutna u visokim nivoima u urinu, kad postoji problem sa bubrezima.
Aminopeptidaza N je locirana u malim crevima i renalnoj mikrovilarnoj membrani, kao i drugim ćelijskim membranama. U tankim crevima aminopeptidaza N učestvuje u finalnom stupnju varenja peptida generisanih hidrolizom proteina gastričnim i pankreatičkim proteazama. Njena funkcija u epitelu i drugim tipovima ćelija nije potpuno razjašnjena. Veliki ekstracelularni karboksiterminalni domen sadrži pentapeptidnu konsenzus sekvencu koja je karakteristična za članove zink-vezujuće metaloproteinazne superfamilije. Poređenjem sekvence sa poznatim enzimima ove klase je pokazalo da su CD13 i aminopeptidaza N identični.[1]
Reference
- ↑ „Entrez Gene: ANPEP alanyl (membrane) aminopeptidase (aminopeptidase N, aminopeptidase M, microsomal aminopeptidase, CD13, p150)”.
Literatura
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.
- Yeager CL, Ashmun RA, Williams RK, et al. (1992). „Human aminopeptidase N is a receptor for human coronavirus 229E”. Nature 357 (6377): 420–2. DOI:10.1038/357420a0. PMID 1350662.
- Shapiro LH, Ashmun RA, Roberts WM, Look AT (1991). „Separate promoters control transcription of the human aminopeptidase N gene in myeloid and intestinal epithelial cells”. J. Biol. Chem. 266 (18): 11999–2007. PMID 1675638.
- O'Connell PJ, Gerkis V, d'Apice AJ (1991). „Variable O-glycosylation of CD13 (aminopeptidase N)”. J. Biol. Chem. 266 (7): 4593–7. PMID 1705556.
- Watt VM, Willard HF (1990). „The human aminopeptidase N gene: isolation, chromosome localization, and DNA polymorphism analysis”. Hum. Genet. 85 (6): 651–4. DOI:10.1007/BF00193592. PMID 1977688.
- Look AT, Peiper SC, Rebentisch MB, et al. (1986). „Molecular cloning, expression, and chromosomal localization of the gene encoding a human myeloid membrane antigen (gp150)”. J. Clin. Invest. 78 (4): 914–21. DOI:10.1172/JCI112680. PMC 423717. PMID 2428842.
- Look AT, Ashmun RA, Shapiro LH, Peiper SC (1989). „Human myeloid plasma membrane glycoprotein CD13 (gp150) is identical to aminopeptidase N”. J. Clin. Invest. 83 (4): 1299–307. DOI:10.1172/JCI114015. PMC 303821. PMID 2564851.
- Olsen J, Cowell GM, Kønigshøfer E, et al. (1988). „Complete amino acid sequence of human intestinal aminopeptidase N as deduced from cloned cDNA”. FEBS Lett. 238 (2): 307–14. DOI:10.1016/0014-5793(88)80502-7. PMID 2901990.
- Kruse TA, Bolund L, Grzeschik KH, et al. (1988). „Assignment of the human aminopeptidase N (peptidase E) gene to chromosome 15q13-qter”. FEBS Lett. 239 (2): 305–8. DOI:10.1016/0014-5793(88)80940-2. PMID 2903074.
- Tokioka-Terao M, Hiwada K, Kokubu T (1985). „Purification and characterization of aminopeptidase N from human plasma”. Enzyme 32 (2): 65–75. PMID 6149934.
- Watanabe Y, Iwaki-Egawa S, Mizukoshi H, Fujimoto Y (1995). „Identification of an alanine aminopeptidase in human maternal serum as a membrane-bound aminopeptidase N”. Biol. Chem. Hoppe-Seyler 376 (7): 397–400. DOI:10.1515/bchm3.1995.376.7.397. PMID 7576235.
- Favaloro EJ, Browning T, Facey D (1993). „CD13 (GP150; aminopeptidase-N): predominant functional activity in blood is localized to plasma and is not cell-surface associated”. Exp. Hematol. 21 (13): 1695–701. PMID 7902291.
- Núñez L, Amigo L, Rigotti A, et al. (1993). „Cholesterol crystallization-promoting activity of aminopeptidase-N isolated from the vesicular carrier of biliary lipids”. FEBS Lett. 329 (1-2): 84–8. DOI:10.1016/0014-5793(93)80199-5. PMID 8102610.
- Söderberg C, Giugni TD, Zaia JA, et al. (1993). „CD13 (human aminopeptidase N) mediates human cytomegalovirus infection”. J. Virol. 67 (11): 6576–85. PMC 238095. PMID 8105105.
- Kolb AF, Maile J, Heister A, Siddell SG (1996). „Characterization of functional domains in the human coronavirus HCV 229E receptor”. J. Gen. Virol.. 77 ( Pt 10): 2515–21. PMID 8887485.
- Norén K, Hansen GH, Clausen H, et al. (1997). „Defectively N-glycosylated and non-O-glycosylated aminopeptidase N (CD13) is normally expressed at the cell surface and has full enzymatic activity”. Exp. Cell Res. 231 (1): 112–8. DOI:10.1006/excr.1996.3455. PMID 9056417.
- Kolb AF, Hegyi A, Siddell SG (1997). „Identification of residues critical for the human coronavirus 229E receptor function of human aminopeptidase N”. J. Gen. Virol.. 78 ( Pt 11): 2795–802. PMID 9367365.
- Hegyi A, Kolb AF (1998). „Characterization of determinants involved in the feline infectious peritonitis virus receptor function of feline aminopeptidase N”. J. Gen. Virol.. 79 ( Pt 6): 1387–91. PMID 9634079.
- Dong X, An B, Salvucci Kierstead L, et al. (2000). „Modification of the amino terminus of a class II epitope confers resistance to degradation by CD13 on dendritic cells and enhances presentation to T cells”. J. Immunol. 164 (1): 129–35. PMID 10605003.
- Pasqualini R, Koivunen E, Kain R, et al. (2000). „Aminopeptidase N is a receptor for tumor-homing peptides and a target for inhibiting angiogenesis”. Cancer Res. 60 (3): 722–7. PMID 10676659.
- Renold A, Cescato R, Beuret N, et al. (2000). „Basolateral sorting signals differ in their ability to redirect apical proteins to the basolateral cell surface”. J. Biol. Chem. 275 (13): 9290–5. DOI:10.1074/jbc.275.13.9290. PMID 10734069.
Vanjske veze
- The MEROPS online database for peptidases and their inhibitors Arhivirano 2019-09-25 na Wayback Machine-u
- MeSH CD13+Antigens
- p
- r
- u
CD1 (a-c, 1A, 1D, 1E) • CD2 • CD3 (γ, δ, ε) • CD4 • CD5 • CD6 • CD7 • CD8 (a) • CD9 • CD10 • CD11 (a, b, c) • CD13 • CD14 • CD15 • CD16 (A, B) • CD18 • CD19 • CD20 • CD21 • CD22 • CD23 • CD24 • CD25 • CD26 • CD27 • CD28 • CD29 • CD30 • CD31 • CD32 (A, B) • CD33 • CD34 • CD35 • CD36 • CD37 • CD38 • CD39 • CD40 • CD41 • CD42 (a, b, c, d) • CD43 • CD44 • CD45 • CD46 • CD47 • CD48 • CD49 (a, b, c, d, e, f) • CD50
CD51 • CD52 • CD53 • CD54 • CD55 • CD56 • CD57 • CD58 • CD59 • CD61 • CD62 (E, L, P) • CD63 • CD64 (A, B, C) • CD66 (a, b, c, d, e, f) • CD68 • CD69 • CD70 • CD71 • CD72 • CD73 • CD74 • CD78 • CD79 (a, b) • CD80 • CD81 • CD82 • CD83 • CD84 • CD85 (a, d, e, h, j, k) • CD86 • CD87 • CD88 • CD89 • CD90 • CD91- CD92 • CD93 • CD94 • CD95 • CD96 • CD97 • CD98 • CD99 • CD100
CD101 • CD102 • CD103 • CD104 • CD105 • CD106 • CD107 (a, b) • CD108 • CD109 • CD110 • CD111 • CD112 • CD113 • CD114 • CD115 • CD116 • CD117 • CD118 • CD119 • CD120 (a, b) • CD121 (a, b) • CD122 • CD123 • CD124 • CD125 • CD126 • CD127 • CD129 • CD130 • CD131 • CD132 • CD133 • CD134 • CD135 • CD136 • CD137 • CD138 • CD140b • CD141 • CD142 • CD143 • CD144 • CD146 • CD147 • CD148 • CD150
CD151 • CD152 • CD153 • CD154 • CD155 • CD156 (a, b, c) • CD157 • CD158 (a, d, e, i, k) • CD159 (a, c) • CD160 • CD161 • CD162 • CD163 • CD164 • CD166 • CD167 (a, b) • CD168 • CD169 • CD170 • CD171 • CD172 (a, b, g) • CD174 • CD177 • CD178 • CD179 (a, b) • CD181 • CD182 • CD183 • CD184 • CD185 • CD186 • CD191 • CD192 • CD193 • CD194 • CD195 • CD196 • CD197 • CDw198 • CDw199 • CD200
CD201 • CD202b • CD204 • CD205 • CD206 • CD207 • CD208 • CD209 • CDw210 (a, b) • CD212 • CD213a (1, 2) • CD217 • CD218 (a, b) • CD220 • CD221 • CD222 • CD223 • CD224 • CD225 • CD226 • CD227 • CD228 • CD229 • CD230 • CD233 • CD234 • CD235 (a, b) • CD236 • CD238 • CD239 • CD240CE • CD241 • CD243 • CD244 • CD246 • CD247- CD248 • CD249
CD252 • CD253 • CD254 • CD256 • CD257 • CD258 • CD261 • CD262 • CD264 • CD265 • CD266 • CD267 • CD268 • CD269 • CD271 • CD272 • CD273 • CD274 • CD275 • CD276 • CD278 • CD279 • CD280 • CD281 • CD282 • CD283 • CD284 • CD286 • CD288 • CD289 • CD290 • CD292 • CDw293 • CD294 • CD295 • CD297 • CD298 • CD299
