Zinc finger protein 334

Protein found in humans
ZNF334
Identifiers
AliasesZNF334, zinc finger protein 334
External IDsMGI: 2388656; HomoloGene: 23076; GeneCards: ZNF334; OMA:ZNF334 - orthologs
Gene location (Mouse)
Chromosome 2 (mouse)
Chr.Chromosome 2 (mouse)[1]
Chromosome 2 (mouse)
Genomic location for ZNF334
Genomic location for ZNF334
Band2|2 H3Start165,216,184 bp[1]
End165,230,179 bp[1]
Gene ontology
Molecular function
  • DNA-binding transcription factor activity
  • DNA binding
  • metal ion binding
  • nucleic acid binding
  • protein binding
  • DNA-binding transcription factor activity, RNA polymerase II-specific
Cellular component
  • intracellular anatomical structure
  • nucleus
Biological process
  • regulation of transcription, DNA-templated
  • transcription, DNA-templated
  • regulation of transcription by RNA polymerase II
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

55713

228876

Ensembl

ENSG00000198185

ENSMUSG00000017667

UniProt

Q9HCZ1

A2A4U6

RefSeq (mRNA)

NM_001270497
NM_018102
NM_199441

NM_178411

RefSeq (protein)
NP_001257426
NP_060572
NP_001340742
NP_001340743
NP_001340744

NP_001340745
NP_001340746
NP_001340747
NP_001340748
NP_001340749
NP_001340750
NP_001340751
NP_001340752
NP_001340753
NP_001340754
NP_001340755
NP_955473

NP_848498

Location (UCSC)n/aChr 2: 165.22 – 165.23 Mb
PubMed search[2][3]
Wikidata
View/Edit HumanView/Edit Mouse

Zinc finger protein 334 is a protein that in humans is encoded by the ZNF334 gene. [4]

Function

This gene encodes a member of the C2H2 zinc finger family. The encoded protein contains a Krueppel-associated box, fourteen C2H2 zinc finger domains, and four C2H2-type/integrase DNA-binding domains. Decreased expression of this gene may be a marker for rheumatoid arthritis. Alternative splicing results in multiple transcript variants that encode different protein isoforms.

References

  1. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000017667 – Ensembl, May 2017
  2. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Entrez Gene: Zinc finger protein 334". Retrieved 2016-03-10.

Further reading

  • Henc I, Soroczyńska-Cybula M, Bryl E, Witkowski JM (2015). "The in vitro modulatory effect of TNFα on the mRNA expression and protein levels of zinc finger protein ZNF334 in CD4(+) lymphocytes of healthy people". Acta Biochim. Pol. 62 (1): 113–7. doi:10.18388/abp.2014_857. PMID 25738173.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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