WDR1

Protein-coding gene in the species Homo sapiens
WDR1
Identifiers
AliasesWDR1, AIP1, HEL-S-52, NORI-1, WD repeat domain 1, PFITS
External IDsOMIM: 604734; MGI: 1337100; HomoloGene: 6628; GeneCards: WDR1; OMA:WDR1 - orthologs
Gene location (Human)
Chromosome 4 (human)
Chr.Chromosome 4 (human)[1]
Chromosome 4 (human)
Genomic location for WDR1
Genomic location for WDR1
Band4p16.1Start10,074,339 bp[1]
End10,116,949 bp[1]
Gene location (Mouse)
Chromosome 5 (mouse)
Chr.Chromosome 5 (mouse)[2]
Chromosome 5 (mouse)
Genomic location for WDR1
Genomic location for WDR1
Band5 B3|5 20.63 cMStart38,684,156 bp[2]
End38,720,564 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • popliteal artery

  • tibial arteries

  • smooth muscle tissue

  • right coronary artery

  • body of uterus

  • saphenous vein

  • stromal cell of endometrium

  • parotid gland

  • thoracic aorta

  • mucosa of sigmoid colon
Top expressed in
  • ankle joint

  • granulocyte

  • mesenteric lymph nodes

  • stroma of bone marrow

  • transitional epithelium of urinary bladder

  • corneal stroma

  • mucous cell of stomach

  • tibiofemoral joint

  • left colon

  • molar
More reference expression data
BioGPS




More reference expression data
Gene ontology
Molecular function
  • actin binding
  • actin filament binding
Cellular component
  • extracellular region
  • myelin sheath
  • podosome
  • cell junction
  • cell projection
  • extracellular exosome
  • cytoskeleton
  • actin filament
  • cell-cell junction
  • cytoplasm
  • cytosol
  • cortical actin cytoskeleton
  • plasma membrane
Biological process
  • platelet degranulation
  • hearing
  • actin cytoskeleton organization
  • regulation of ventricular cardiac muscle cell membrane repolarization
  • regulation of oligodendrocyte differentiation
  • maintenance of epithelial cell apical/basal polarity
  • apical junction assembly
  • regulation of actin filament depolymerization
  • neutrophil mediated immunity
  • regulation of cell shape
  • actin filament fragmentation
  • platelet formation
  • positive regulation of actin filament depolymerization
  • cortical cytoskeleton organization
  • locomotion
  • establishment of planar polarity of follicular epithelium
  • sarcomere organization
  • neutrophil migration
  • actin filament depolymerization
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

9948

22388

Ensembl

ENSG00000071127

ENSMUSG00000005103

UniProt

O75083

O88342

RefSeq (mRNA)

NM_005112
NM_017491

NM_011715

RefSeq (protein)

NP_005103
NP_059830

NP_035845

Location (UCSC)Chr 4: 10.07 – 10.12 MbChr 5: 38.68 – 38.72 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

WD repeat-containing protein 1 is a protein that in humans is encoded by the WDR1 gene.[5][6]

This gene encodes a protein containing 9 WD repeats. WD repeats are approximately 30- to 40-amino acid domains containing several conserved residues, mostly including a trp-asp at the C-terminal end. WD domains are involved in protein-protein interactions. The encoded protein may help induce the disassembly of actin filaments. Two transcript variants encoding different isoforms have been found for this gene.[6]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000071127 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000005103 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Adler HJ, Winnicki RS, Gong TW, Lomax MI (May 1999). "A gene upregulated in the acoustically damaged chick basilar papilla encodes a novel WD40 repeat protein". Genomics. 56 (1): 59–69. doi:10.1006/geno.1998.5672. PMID 10036186.
  6. ^ a b "Entrez Gene: WDR1 WD repeat domain 1".

Further reading

  • Dawson SJ, White LA (1992). "Treatment of Haemophilus aphrophilus endocarditis with ciprofloxacin". J. Infect. 24 (3): 317–20. doi:10.1016/S0163-4453(05)80037-4. PMID 1602151.
  • Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
  • Rodal AA, Tetreault JW, Lappalainen P, et al. (1999). "Aip1p interacts with cofilin to disassemble actin filaments". J. Cell Biol. 145 (6): 1251–64. doi:10.1083/jcb.145.6.1251. PMC 2133144. PMID 10366597.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Gevaert K, Goethals M, Martens L, et al. (2004). "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides". Nat. Biotechnol. 21 (5): 566–9. doi:10.1038/nbt810. PMID 12665801. S2CID 23783563.
  • Lehner B, Sanderson CM (2004). "A protein interaction framework for human mRNA degradation". Genome Res. 14 (7): 1315–23. doi:10.1101/gr.2122004. PMC 442147. PMID 15231747.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Rush J, Moritz A, Lee KA, et al. (2005). "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells". Nat. Biotechnol. 23 (1): 94–101. doi:10.1038/nbt1046. PMID 15592455. S2CID 7200157.
  • Fujibuchi T, Abe Y, Takeuchi T, et al. (2005). "AIP1/WDR1 supports mitotic cell rounding". Biochem. Biophys. Res. Commun. 327 (1): 268–75. doi:10.1016/j.bbrc.2004.11.156. PMID 15629458.
  • Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.


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