TMEPAI

Protein-coding gene in the species Homo sapiens
PMEPA1
Identifiers
AliasesPMEPA1, STAG1, TMEPAI, prostate transmembrane protein, androgen induced 1
External IDsOMIM: 606564; MGI: 1929600; HomoloGene: 10608; GeneCards: PMEPA1; OMA:PMEPA1 - orthologs
Gene location (Human)
Chromosome 20 (human)
Chr.Chromosome 20 (human)[1]
Chromosome 20 (human)
Genomic location for PMEPA1
Genomic location for PMEPA1
Band20q13.31Start57,648,392 bp[1]
End57,711,536 bp[1]
Gene location (Mouse)
Chromosome 2 (mouse)
Chr.Chromosome 2 (mouse)[2]
Chromosome 2 (mouse)
Genomic location for PMEPA1
Genomic location for PMEPA1
Band2|2 H3Start173,066,251 bp[2]
End173,118,326 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • visceral pleura

  • ascending aorta

  • Descending thoracic aorta

  • popliteal artery

  • tibial arteries

  • tibia

  • tendon of biceps brachii

  • canal of the cervix

  • urethra

  • prostate
Top expressed in
  • ascending aorta

  • aortic valve

  • external carotid artery

  • internal carotid artery

  • tunica media of zone of aorta

  • brown adipose tissue

  • subcutaneous adipose tissue

  • interventricular septum

  • white adipose tissue

  • sciatic nerve
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • WW domain binding
  • R-SMAD binding
  • protein binding
Cellular component
  • integral component of membrane
  • Golgi membrane
  • endosome
  • plasma membrane
  • Golgi apparatus
  • early endosome membrane
  • endosome membrane
  • intracellular membrane-bounded organelle
  • membrane
Biological process
  • androgen receptor signaling pathway
  • negative regulation of signal transduction
  • negative regulation of transforming growth factor beta receptor signaling pathway
  • negative regulation of pathway-restricted SMAD protein phosphorylation
  • negative regulation of SMAD protein complex assembly
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

56937

65112

Ensembl

ENSG00000124225

ENSMUSG00000038400

UniProt

Q969W9

Q9D7R2

RefSeq (mRNA)

NM_199171
NM_001255976
NM_020182
NM_199169
NM_199170

NM_022995

RefSeq (protein)

NP_001242905
NP_064567
NP_954638
NP_954639
NP_954640

n/a

Location (UCSC)Chr 20: 57.65 – 57.71 MbChr 2: 173.07 – 173.12 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Transmembrane prostate androgen-induced protein is a protein that in humans is encoded by the PMEPA1 gene.[5][6]

Interactions

TMEPAI has been shown to interact with NEDD4.[7]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000124225 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000038400 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Xu LL, Shanmugam N, Segawa T, Sesterhenn IA, McLeod DG, Moul JW, Srivastava S (Jun 2000). "A novel androgen-regulated gene, PMEPA1, located on chromosome 20q13 exhibits high level expression in prostate". Genomics. 66 (3): 257–63. doi:10.1006/geno.2000.6214. PMID 10873380.
  6. ^ "Entrez Gene: TMEPAI transmembrane, prostate androgen induced RNA".
  7. ^ Xu LL, Shi Y, Petrovics G, Sun C, Makarem M, Zhang W, Sesterhenn IA, McLeod DG, Sun L, Moul JW, Srivastava S (Aug 2003). "PMEPA1, an androgen-regulated NEDD4-binding protein, exhibits cell growth inhibitory function and decreased expression during prostate cancer progression". Cancer Research. 63 (15): 4299–304. PMID 12907594.

Further reading

  • Jolliffe CN, Harvey KF, Haines BP, Parasivam G, Kumar S (Nov 2000). "Identification of multiple proteins expressed in murine embryos as binding partners for the WW domains of the ubiquitin-protein ligase Nedd4". The Biochemical Journal. 351 Pt 3 (3): 557–65. doi:10.1042/0264-6021:3510557. PMC 1221394. PMID 11042109.
  • Rae FK, Hooper JD, Nicol DL, Clements JA (Sep 2001). "Characterization of a novel gene, STAG1/PMEPA1, upregulated in renal cell carcinoma and other solid tumors". Molecular Carcinogenesis. 32 (1): 44–53. doi:10.1002/mc.1063. PMID 11568975. S2CID 46602128.
  • Brunschwig EB, Wilson K, Mack D, Dawson D, Lawrence E, Willson JK, Lu S, Nosrati A, Rerko RM, Swinler S, Beard L, Lutterbaugh JD, Willis J, Platzer P, Markowitz S (Apr 2003). "PMEPA1, a transforming growth factor-beta-induced marker of terminal colonocyte differentiation whose expression is maintained in primary and metastatic colon cancer". Cancer Research. 63 (7): 1568–75. PMID 12670906.
  • Xu LL, Shi Y, Petrovics G, Sun C, Makarem M, Zhang W, Sesterhenn IA, McLeod DG, Sun L, Moul JW, Srivastava S (Aug 2003). "PMEPA1, an androgen-regulated NEDD4-binding protein, exhibits cell growth inhibitory function and decreased expression during prostate cancer progression". Cancer Research. 63 (15): 4299–304. PMID 12907594.
  • Giannini G, Ambrosini MI, Di Marcotullio L, Cerignoli F, Zani M, MacKay AR, Screpanti I, Frati L, Gulino A (Dec 2003). "EGF- and cell-cycle-regulated STAG1/PMEPA1/ERG1.2 belongs to a conserved gene family and is overexpressed and amplified in breast and ovarian cancer". Molecular Carcinogenesis. 38 (4): 188–200. doi:10.1002/mc.10162. PMID 14639658. S2CID 22894125.
  • Lim J, Hao T, Shaw C, Patel AJ, Szabó G, Rual JF, Fisk CJ, Li N, Smolyar A, Hill DE, Barabási AL, Vidal M, Zoghbi HY (May 2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell. 125 (4): 801–14. doi:10.1016/j.cell.2006.03.032. PMID 16713569. S2CID 13709685.


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