TIRAP |
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Available structures |
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PDB | Ortholog search: PDBe RCSB |
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List of PDB id codes |
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2Y92, 3UB2, 3UB3, 3UB4, 4FZ5, 4LQD |
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Identifiers |
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Aliases | TIRAP, BACTS1, Mal, MyD88-2, wyatt, toll-interleukin 1 receptor (TIR) domain containing adaptor protein, TIR domain containing adaptor protein |
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External IDs | OMIM: 606252; MGI: 2152213; HomoloGene: 14285; GeneCards: TIRAP; OMA:TIRAP - orthologs |
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Gene location (Human) |
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| Chr. | Chromosome 11 (human)[1] |
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| Band | 11q24.2 | Start | 126,283,065 bp[1] |
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End | 126,298,845 bp[1] |
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Gene location (Mouse) |
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| Chr. | Chromosome 9 (mouse)[2] |
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| Band | 9|9 A4 | Start | 35,095,847 bp[2] |
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End | 35,111,587 bp[2] |
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RNA expression pattern |
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Bgee | Human | Mouse (ortholog) |
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Top expressed in | - monocyte
- bone marrow cells
- islet of Langerhans
- rectum
- smooth muscle tissue
- right lobe of liver
- minor salivary glands
- stromal cell of endometrium
- gallbladder
- appendix
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| Top expressed in | - triceps brachii muscle
- vastus lateralis muscle
- conjunctival fornix
- sternocleidomastoid muscle
- primitive streak
- temporal muscle
- knee joint
- parotid gland
- cumulus cell
- otic placode
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| More reference expression data |
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BioGPS | |
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Gene ontology |
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Molecular function | - protein-macromolecule adaptor activity
- protein homodimerization activity
- Toll-like receptor 2 binding
- Toll-like receptor 4 binding
- protein binding
- protein heterodimerization activity
- phosphatidylinositol-4,5-bisphosphate binding
- protein kinase C binding
- identical protein binding
| Cellular component | - cytoplasm
- cytosol
- membrane
- plasma membrane
- endocytic vesicle
- ruffle membrane
| Biological process | - myeloid cell differentiation
- regulation of innate immune response
- cellular response to bacterial lipopeptide
- positive regulation of toll-like receptor 3 signaling pathway
- positive regulation of interleukin-12 production
- positive regulation of chemokine (C-X-C motif) ligand 1 production
- positive regulation of chemokine (C-X-C motif) ligand 2 production
- immune system process
- positive regulation of JNK cascade
- MyD88-dependent toll-like receptor signaling pathway
- positive regulation of interleukin-15 production
- positive regulation of protein homodimerization activity
- cell surface receptor signaling pathway
- response to lipopolysaccharide
- TIRAP-dependent toll-like receptor 4 signaling pathway
- cellular response to lipoteichoic acid
- positive regulation of B cell proliferation
- regulation of interferon-beta production
- positive regulation of NF-kappaB transcription factor activity
- positive regulation of interleukin-8 production
- positive regulation of ERK1 and ERK2 cascade
- positive regulation of neutrophil chemotaxis
- positive regulation of tumor necrosis factor production
- positive regulation of toll-like receptor 4 signaling pathway
- positive regulation of I-kappaB kinase/NF-kappaB signaling
- positive regulation of toll-like receptor 2 signaling pathway
- 3'-UTR-mediated mRNA stabilization
- inflammatory response
- signal transduction
- defense response to Gram-positive bacterium
- innate immune response
- activation of NF-kappaB-inducing kinase activity
| Sources:Amigo / QuickGO |
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Orthologs |
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Species | Human | Mouse |
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Entrez | | |
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Ensembl | | |
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UniProt | | |
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RefSeq (mRNA) | |
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NM_001039661 NM_052887 NM_148910 NM_001318776 NM_001318777 |
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NM_001177845 NM_001177846 NM_001177847 NM_054096 |
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RefSeq (protein) | |
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NP_001034750 NP_001305705 NP_001305706 NP_683708 |
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NP_001171316 NP_001171317 NP_001171318 NP_473437 |
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Location (UCSC) | Chr 11: 126.28 – 126.3 Mb | Chr 9: 35.1 – 35.11 Mb |
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PubMed search | [3] | [4] |
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Wikidata |
View/Edit Human | View/Edit Mouse |
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