SUPT6H

Protein-coding gene in the species Homo sapiens
SUPT6H
Identifiers
AliasesSUPT6H, SPT6, SPT6H, emb-5, SPT6 homolog, histone chaperone, SPT6 homolog, histone chaperone and transcription elongation factor
External IDsOMIM: 601333; MGI: 107726; HomoloGene: 40661; GeneCards: SUPT6H; OMA:SUPT6H - orthologs
Gene location (Human)
Chromosome 17 (human)
Chr.Chromosome 17 (human)[1]
Chromosome 17 (human)
Genomic location for SUPT6H
Genomic location for SUPT6H
Band17q11.2Start28,662,198 bp[1]
End28,702,679 bp[1]
Gene location (Mouse)
Chromosome 11 (mouse)
Chr.Chromosome 11 (mouse)[2]
Chromosome 11 (mouse)
Genomic location for SUPT6H
Genomic location for SUPT6H
Band11 B5|11 46.74 cMStart78,097,572 bp[2]
End78,136,813 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • sural nerve

  • epithelium of colon

  • stromal cell of endometrium

  • gastric mucosa

  • anterior pituitary

  • skin of leg

  • granulocyte

  • gastrocnemius muscle

  • muscle layer of sigmoid colon

  • left adrenal cortex
Top expressed in
  • dentate gyrus of hippocampal formation granule cell

  • neural layer of retina

  • tail of embryo

  • zygote

  • primary visual cortex

  • yolk sac

  • superior frontal gyrus

  • genital tubercle

  • otic vesicle

  • muscle of thigh
More reference expression data
BioGPS


More reference expression data
Gene ontology
Molecular function
  • DNA binding
  • DNA-binding transcription factor activity
  • histone binding
  • protein binding
  • nucleic acid binding
  • nucleosome binding
  • RNA binding
Cellular component
  • nucleus
  • nucleoplasm
  • transcription elongation factor complex
Biological process
  • chromatin remodeling
  • negative regulation of histone H3-K27 methylation
  • mRNA transport
  • regulation of transcription, DNA-templated
  • regulation of muscle cell differentiation
  • regulation of mRNA export from nucleus
  • regulation of transcription by RNA polymerase II
  • mRNA processing
  • regulation of DNA-templated transcription, elongation
  • transcription, DNA-templated
  • RNA splicing
  • regulation of isotype switching
  • viral process
  • nucleobase-containing compound metabolic process
  • positive regulation of transcription elongation from RNA polymerase II promoter
  • transcription by RNA polymerase II
  • transcription elongation from RNA polymerase II promoter
  • nucleosome organization
  • mRNA transcription by RNA polymerase II
  • regulation of mRNA processing
  • transport
  • blastocyst formation
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

6830

20926

Ensembl

ENSG00000109111

ENSMUSG00000002052

UniProt

Q7KZ85

Q62383

RefSeq (mRNA)

NM_003170
NM_001320755

NM_009297

RefSeq (protein)

NP_001307684
NP_003161

NP_033323

Location (UCSC)Chr 17: 28.66 – 28.7 MbChr 11: 78.1 – 78.14 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Transcription elongation factor SPT6 is a protein that in humans is encoded by the SUPT6H gene.[5][6]


References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000109111 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000002052 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Chiang PW, Wang S, Smithivas P, Song WJ, Ramamoorthy S, Hillman J, Puett S, Van Keuren ML, Crombez E, Kumar A, Glover TW, Miller DE, Tsai CH, Blackburn CC, Chen XN, Sun Z, Cheng JF, Korenberg JR, Kurnit DM (Sep 1996). "Identification and analysis of the human and murine putative chromatin structure regulator SUPT6H and Supt6h". Genomics. 34 (3): 328–33. doi:10.1006/geno.1996.0294. PMID 8786132.
  6. ^ "Entrez Gene: SUPT6H suppressor of Ty 6 homolog (S. cerevisiae)".

Further reading

  • Andersson B, Wentland MA, Ricafrente JY, et al. (1996). "A "double adaptor" method for improved shotgun library construction". Anal. Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474.
  • Nagase T, Seki N, Ishikawa K, et al. (1996). "Prediction of the coding sequences of unidentified human genes. V. The coding sequences of 40 new genes (KIAA0161-KIAA0200) deduced by analysis of cDNA clones from human cell line KG-1". DNA Res. 3 (1): 17–24. doi:10.1093/dnares/3.1.17. PMID 8724849.
  • Yu W, Andersson B, Worley KC, et al. (1997). "Large-scale concatenation cDNA sequencing". Genome Res. 7 (4): 353–8. doi:10.1101/gr.7.4.353. PMC 139146. PMID 9110174.
  • Chiang PW, Stubbs L, Zhang L, Kurnit DM (1998). "Isolation of murine SPT5 homologue: completion of the isolation and characterization of human and murine homologues of yeast chromatin structural protein complex SPT4, SPT5, and SPT6". Genomics. 47 (3): 426–8. doi:10.1006/geno.1997.5137. PMID 9480761.
  • Wu-Baer F, Lane WS, Gaynor RB (1998). "Role of the human homolog of the yeast transcription factor SPT5 in HIV-1 Tat-activation". J. Mol. Biol. 277 (2): 179–97. doi:10.1006/jmbi.1997.1601. PMID 9514752.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Endoh M, Zhu W, Hasegawa J, et al. (2004). "Human Spt6 stimulates transcription elongation by RNA polymerase II in vitro". Mol. Cell. Biol. 24 (8): 3324–36. doi:10.1128/MCB.24.8.3324-3336.2004. PMC 381665. PMID 15060154.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.


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