SNX15

Protein-coding gene in the species Homo sapiens
SNX15
Identifiers
AliasesSNX15, HSAF001435, sorting nexin 15
External IDsOMIM: 605964; MGI: 1916274; HomoloGene: 12294; GeneCards: SNX15; OMA:SNX15 - orthologs
Gene location (Mouse)
Chromosome 19 (mouse)
Chr.Chromosome 19 (mouse)[1]
Chromosome 19 (mouse)
Genomic location for SNX15
Genomic location for SNX15
Band19|19 AStart6,169,429 bp[1]
End6,178,334 bp[1]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • bone marrow cells

  • prefrontal cortex

  • cerebellar hemisphere

  • monocyte

  • skeletal muscle tissue

  • gastrocnemius muscle

  • popliteal artery

  • right coronary artery

  • Brodmann area 9

  • amygdala
Top expressed in
  • blood

  • neural layer of retina

  • superior frontal gyrus

  • fetal liver hematopoietic progenitor cell

  • islet of Langerhans

  • yolk sac

  • lip

  • gastric mucosa

  • primary visual cortex

  • epithelium of stomach
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
  • protein binding
  • phosphatidylinositol binding
  • lipid binding
Cellular component
  • nucleolus
  • cytoplasmic vesicle membrane
  • membrane
  • cytoplasmic vesicle
  • cytoplasm
  • cytosol
Biological process
  • protein transport
  • signal transduction
  • intracellular protein transport
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

29907

69024

Ensembl

n/a

ENSMUSG00000024787

UniProt

Q9NRS6

Q91WE1

RefSeq (mRNA)

NM_147777
NM_013306

NM_026912

RefSeq (protein)

NP_037438
NP_680086

NP_081188

Location (UCSC)n/aChr 19: 6.17 – 6.18 Mb
PubMed search[2][3]
Wikidata
View/Edit HumanView/Edit Mouse

Sorting nexin-15 is a protein that in humans is encoded by the SNX15 gene.[4][5]

This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. Overexpression of this gene results in a decrease in the processing of insulin and hepatocyte growth factor receptors to their mature subunits. This decrease is caused by the mislocalization of furin, the endoprotease responsible for cleavage of insulin and hepatocyte growth factor receptors. This protein is involved in endosomal trafficking from the plasma membranee to recycling endosomes or the trans-Golgi network. This gene encodes two transcript variants encoding distinct isoforms.[5]

References

  1. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000024787 – Ensembl, May 2017
  2. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ Barr VA, Phillips SA, Taylor SI, Haft CR (Mar 2001). "Overexpression of a novel sorting nexin, SNX15, affects endosome morphology and protein trafficking". Traffic. 1 (11): 904–16. doi:10.1034/j.1600-0854.2000.011109.x. PMID 11208079. S2CID 31092568.
  5. ^ a b "Entrez Gene: SNX15 sorting nexin 15".

Further reading

  • Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
  • Guru SC, Agarwal SK, Manickam P, et al. (1997). "A transcript map for the 2.8-Mb region containing the multiple endocrine neoplasia type 1 locus". Genome Res. 7 (7): 725–35. doi:10.1101/gr.7.7.725. PMC 310681. PMID 9253601.
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
  • Phillips SA, Barr VA, Haft DH, et al. (2001). "Identification and characterization of SNX15, a novel sorting nexin involved in protein trafficking". J. Biol. Chem. 276 (7): 5074–84. doi:10.1074/jbc.M004671200. PMID 11085978.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
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