SERINC3

Protein-coding gene in the species Homo sapiens
SERINC3
Identifiers
AliasesSERINC3, AIGP1, DIFF33, SBBI99, TDE, TDE1, TMS-1, serine incorporator 3
External IDsOMIM: 607165; MGI: 1349457; HomoloGene: 38230; GeneCards: SERINC3; OMA:SERINC3 - orthologs
Gene location (Human)
Chromosome 20 (human)
Chr.Chromosome 20 (human)[1]
Chromosome 20 (human)
Genomic location for SERINC3
Genomic location for SERINC3
Band20q13.12Start44,496,221 bp[1]
End44,522,085 bp[1]
Gene location (Mouse)
Chromosome 2 (mouse)
Chr.Chromosome 2 (mouse)[2]
Chromosome 2 (mouse)
Genomic location for SERINC3
Genomic location for SERINC3
Band2|2 H3Start163,465,192 bp[2]
End163,487,051 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • endothelial cell

  • tendon of biceps brachii

  • pons

  • internal globus pallidus

  • Brodmann area 23

  • middle temporal gyrus

  • superior frontal gyrus

  • stromal cell of endometrium

  • postcentral gyrus

  • prefrontal cortex
Top expressed in
  • lobe of prostate

  • seminal vesicula

  • stroma of bone marrow

  • left lung lobe

  • blood

  • Paneth cell

  • median eminence

  • parotid gland

  • Gonadal ridge

  • crypt of lieberkuhn of small intestine
More reference expression data
BioGPS




More reference expression data
Gene ontology
Molecular function
  • L-serine transmembrane transporter activity
Cellular component
  • integral component of membrane
  • Golgi membrane
  • Golgi apparatus
  • membrane
  • cytoplasm
  • perinuclear region of cytoplasm
  • plasma membrane
Biological process
  • phosphatidylserine metabolic process
  • detection of virus
  • innate immune response
  • defense response to virus
  • positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
  • sphingolipid metabolic process
  • L-serine transport
  • immune system process
  • L-serine biosynthetic process
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

10955

26943

Ensembl

ENSG00000132824

ENSMUSG00000017707

UniProt

Q13530

Q9QZI9

RefSeq (mRNA)

NM_198941
NM_006811

NM_012032

RefSeq (protein)

NP_006802
NP_945179

NP_036162

Location (UCSC)Chr 20: 44.5 – 44.52 MbChr 2: 163.47 – 163.49 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Serine incorporator 3 is a protein that in humans is encoded by the SERINC3 gene.[5][6] It has been demonstrated that SERINC3 acts as a retrovirus restriction factor. [7][8][9]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000132824 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000017707 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Bossolasco M, Lebel M, Lemieux N, Mes-Masson AM (November 1999). "The human TDE gene homologue: localization to 20q13.1-13.3 and variable expression in human tumor cell lines and tissue". Molecular Carcinogenesis. 26 (3): 189–200. doi:10.1002/(SICI)1098-2744(199911)26:3<189::AID-MC8>3.0.CO;2-T. PMID 10559794. S2CID 19505445.
  6. ^ "Entrez Gene: SERINC3 serine incorporator 3".
  7. ^ Rosa A, Chande A, Ziglio S, De Sanctis V, Bertorelli R, Goh SL, McCauley SM, Nowosielska A, Antonarakis SE, Luban J, Santoni FA, Pizzato M (October 2015). "HIV-1 Nef promotes infection by excluding SERINC5 from virion incorporation". Nature. 526 (7572): 212–7. Bibcode:2015Natur.526..212R. doi:10.1038/nature15399. PMC 4861059. PMID 26416734.
  8. ^ Chande A, Cuccurullo EC, Rosa A, Ziglio S, Carpenter S, Pizzato M (November 2016). "S2 from equine infectious anemia virus is an infectivity factor which counteracts the retroviral inhibitors SERINC5 and SERINC3". Proceedings of the National Academy of Sciences of the United States of America. 113 (46): 13197–13202. doi:10.1073/pnas.1612044113. PMC 5135340. PMID 27803322.
  9. ^ Ramdas P, Bhardwaj V, Singh A, Vijay N, Chande A (2020-02-24). "Coevolution of retroviruses with SERINCs following whole-genome duplication divergence". bioRxiv. doi:10.1101/2020.02.24.962506.

Further reading

  • Adams MD, Kerlavage AR, Fleischmann RD, Fuldner RA, Bult CJ, Lee NH, Kirkness EF, Weinstock KG, Gocayne JD, White O (September 1995). "Initial assessment of human gene diversity and expression patterns based upon 83 million nucleotides of cDNA sequence" (PDF). Nature. 377 (6547 Suppl): 3–174. PMID 7566098.
  • Maruyama K, Sugano S (January 1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
  • Bonaldo MF, Lennon G, Soares MB (September 1996). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Research. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (October 1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
  • Bossolasco M, Veillette F, Bertrand R, Mes-Masson AM (August 2006). "Human TDE1, a TDE1/TMS family member, inhibits apoptosis in vitro and stimulates in vivo tumorigenesis". Oncogene. 25 (33): 4549–58. doi:10.1038/sj.onc.1209488. PMID 16547497. S2CID 24696947.
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