PWP1

Protein-coding gene in the species Homo sapiens
PWP1
Identifiers
AliasesPWP1, IEF-SSP-9502, PWP1 homolog, endonuclein
External IDsMGI: 1914735; HomoloGene: 5129; GeneCards: PWP1; OMA:PWP1 - orthologs
Gene location (Mouse)
Chromosome 10 (mouse)
Chr.Chromosome 10 (mouse)[1]
Chromosome 10 (mouse)
Genomic location for PWP1
Genomic location for PWP1
Band10|10 C1Start85,665,358 bp[1]
End85,724,960 bp[1]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • secondary oocyte

  • nipple

  • pylorus

  • cardia

  • renal medulla

  • pericardium

  • Achilles tendon

  • vulva

  • pons

  • parietal pleura
Top expressed in
  • primitive streak

  • abdominal wall

  • endothelial cell of lymphatic vessel

  • Paneth cell

  • spermatocyte

  • epiblast

  • medial ganglionic eminence

  • morula

  • hair follicle

  • maxillary prominence
More reference expression data
BioGPS




More reference expression data
Gene ontology
Molecular function
  • H4K20me3 modified histone binding
Cellular component
  • nucleus
  • Golgi apparatus
  • nucleolus
  • chromosome
Biological process
  • transcription, DNA-templated
  • positive regulation of stem cell differentiation
  • histone H4-K20 trimethylation
  • negative regulation of peptidyl-serine phosphorylation of STAT protein
  • positive regulation of transcription of nucleolar large rRNA by RNA polymerase I
  • ribosome biogenesis
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

11137

103136

Ensembl

n/a

ENSMUSG00000001785

UniProt

Q13610

Q99LL5

RefSeq (mRNA)

NM_007062
NM_001317962
NM_001317963

NM_133993

RefSeq (protein)

NP_001304891
NP_001304892
NP_008993

NP_598754

Location (UCSC)n/aChr 10: 85.67 – 85.72 Mb
PubMed search[2][3]
Wikidata
View/Edit HumanView/Edit Mouse

Periodic tryptophan protein 1 homolog is a protein that in humans is encoded by the PWP1 gene.[4][5]

References

  1. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000001785 – Ensembl, May 2017
  2. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ Honore B, Leffers H, Madsen P, Celis JE (Feb 1995). "Cloning of a cDNA encoding a novel human nuclear phosphoprotein belonging to the WD-40 family". Gene. 151 (1–2): 291–6. doi:10.1016/0378-1119(94)90673-4. PMID 7828893.
  5. ^ "Entrez Gene: PWP1 PWP1 homolog (S. cerevisiae)".

Further reading

  • Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
  • Gress TM, Müller-Pillasch F, Geng M, et al. (1996). "A pancreatic cancer-specific expression profile". Oncogene. 13 (8): 1819–30. PMID 8895530.
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
  • Andersen JS, Lyon CE, Fox AH, et al. (2002). "Directed proteomic analysis of the human nucleolus". Curr. Biol. 12 (1): 1–11. Bibcode:2002CBio...12....1A. doi:10.1016/S0960-9822(01)00650-9. PMID 11790298. S2CID 14132033.
  • Honoré B, Baandrup U, Nielsen S, Vorum H (2002). "Endonuclein is a cell cycle regulated WD-repeat protein that is up-regulated in adenocarcinoma of the pancreas". Oncogene. 21 (7): 1123–9. doi:10.1038/sj.onc.1205186. PMID 11850830. S2CID 1657629.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. Bibcode:2004PNAS..10112130B. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
  • Barrios-Rodiles M, Brown KR, Ozdamar B, et al. (2005). "High-throughput mapping of a dynamic signaling network in mammalian cells". Science. 307 (5715): 1621–5. Bibcode:2005Sci...307.1621B. doi:10.1126/science.1105776. PMID 15761153. S2CID 39457788.
  • Nousiainen M, Silljé HH, Sauer G, et al. (2006). "Phosphoproteome analysis of the human mitotic spindle". Proc. Natl. Acad. Sci. U.S.A. 103 (14): 5391–6. Bibcode:2006PNAS..103.5391N. doi:10.1073/pnas.0507066103. PMC 1459365. PMID 16565220.
  • Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.


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