PRIC285

Human gene
HELZ2
Identifiers
AliasesHELZ2, PDIP-1, PRIC285, helicase with zinc finger 2
External IDsOMIM: 611265; MGI: 2385169; HomoloGene: 14118; GeneCards: HELZ2; OMA:HELZ2 - orthologs
Gene location (Human)
Chromosome 20 (human)
Chr.Chromosome 20 (human)[1]
Chromosome 20 (human)
Genomic location for HELZ2
Genomic location for HELZ2
Band20q13.33Start63,558,086 bp[1]
End63,574,239 bp[1]
Gene location (Mouse)
Chromosome 2 (mouse)
Chr.Chromosome 2 (mouse)[2]
Chromosome 2 (mouse)
Genomic location for HELZ2
Genomic location for HELZ2
Band2|2 H4Start180,869,408 bp[2]
End180,883,820 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • granulocyte

  • bone marrow cells

  • blood

  • sural nerve

  • appendix

  • monocyte

  • stromal cell of endometrium

  • spleen

  • apex of heart

  • upper lobe of left lung
Top expressed in
  • lymph node

  • epithelium of small intestine

  • mesenteric lymph nodes

  • spleen

  • submandibular gland

  • left lobe of liver

  • blood

  • Paneth cell

  • subcutaneous adipose tissue

  • intestinal villus
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
  • DNA binding
  • nucleotide binding
  • protein binding
  • ATP binding
  • hydrolase activity
  • helicase activity
  • nuclear receptor coactivator activity
  • metal ion binding
  • RNA binding
  • ribonuclease activity
Cellular component
  • membrane
  • nucleus
  • nucleoplasm
  • cytoplasm
Biological process
  • regulation of transcription, DNA-templated
  • transcription, DNA-templated
  • positive regulation of transcription by RNA polymerase II
  • regulation of lipid metabolic process
  • nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
  • RNA phosphodiester bond hydrolysis
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

85441

229003

Ensembl

ENSG00000130589

ENSMUSG00000027580

UniProt

Q9BYK8

E9QAM5

RefSeq (mRNA)

NM_001037335
NM_033405

NM_183162

RefSeq (protein)

NP_001032412
NP_208384

NP_898985

Location (UCSC)Chr 20: 63.56 – 63.57 MbChr 2: 180.87 – 180.88 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Peroxisomal proliferator-activated receptor A interacting complex 285, also known as PRIC285, is a human gene.[5]

The protein encoded by this gene is a nuclear transcriptional co-activator for peroxisome proliferator activated receptor alpha. The encoded protein contains a zinc finger and is a helicase that appears to be part of the peroxisome proliferator activated receptor alpha interacting complex. This gene is a member of the DNA2/NAM7 helicase gene family. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[5]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000130589 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000027580 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b "Entrez Gene: PRIC285 peroxisomal proliferator-activated receptor A interacting complex 285".

Further reading

  • Nakajima D, Okazaki N, Yamakawa H, et al. (2003). "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones". DNA Res. 9 (3): 99–106. doi:10.1093/dnares/9.3.99. PMID 12168954.
  • Dias Neto E, Correa RG, Verjovski-Almeida S, et al. (2000). "Shotgun sequencing of the human transcriptome with ORF expressed sequence tags". Proc. Natl. Acad. Sci. U.S.A. 97 (7): 3491–6. Bibcode:2000PNAS...97.3491D. doi:10.1073/pnas.97.7.3491. PMC 16267. PMID 10737800.
  • Nagase T, Kikuno R, Hattori A, et al. (2001). "Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 7 (6): 347–55. doi:10.1093/dnares/7.6.347. PMID 11214970.
  • Deloukas P, Matthews LH, Ashurst J, et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20". Nature. 414 (6866): 865–71. Bibcode:2001Natur.414..865D. doi:10.1038/414865a. PMID 11780052.
  • Surapureddi S, Yu S, Bu H, et al. (2002). "Identification of a transcriptionally active peroxisome proliferator-activated receptor alpha -interacting cofactor complex in rat liver and characterization of PRIC285 as a coactivator". Proc. Natl. Acad. Sci. U.S.A. 99 (18): 11836–41. Bibcode:2002PNAS...9911836S. doi:10.1073/pnas.182426699. PMC 129355. PMID 12189208.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. Bibcode:2004PNAS..10112130B. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
  • Tomaru T, Satoh T, Yoshino S, et al. (2006). "Isolation and characterization of a transcriptional cofactor and its novel isoform that bind the deoxyribonucleic acid-binding domain of peroxisome proliferator-activated receptor-gamma". Endocrinology. 147 (1): 377–88. doi:10.1210/en.2005-0450. PMID 16239304.
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