PPP2R2D

Protein-coding gene in the species Homo sapiens
PPP2R2D
Identifiers
AliasesPPP2R2D, MDS026, protein phosphatase 2 regulatory subunit Bdelta, B55delta, B55D
External IDsOMIM: 613992; MGI: 1289252; HomoloGene: 81915; GeneCards: PPP2R2D; OMA:PPP2R2D - orthologs
Gene location (Human)
Chromosome 10 (human)
Chr.Chromosome 10 (human)[1]
Chromosome 10 (human)
Genomic location for PPP2R2D
Genomic location for PPP2R2D
Band10q26.3Start131,901,008 bp[1]
End131,959,834 bp[1]
Gene location (Mouse)
Chromosome 7 (mouse)
Chr.Chromosome 7 (mouse)[2]
Chromosome 7 (mouse)
Genomic location for PPP2R2D
Genomic location for PPP2R2D
Band7 F4|7 82.95 cMStart138,846,079 bp[2]
End138,883,057 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • body of pancreas

  • left ovary

  • muscle of thigh

  • cerebellar hemisphere

  • right adrenal cortex

  • right hemisphere of cerebellum

  • left adrenal gland

  • ganglionic eminence

  • primary visual cortex

  • left adrenal cortex
Top expressed in
  • internal carotid artery

  • facial motor nucleus

  • external carotid artery

  • seminiferous tubule

  • primitive streak

  • endothelial cell of lymphatic vessel

  • right ventricle

  • spermatid

  • brown adipose tissue

  • motor neuron
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
  • protein serine/threonine phosphatase activity
  • protein binding
  • protein phosphatase regulator activity
Cellular component
  • cytoplasm
  • protein phosphatase type 2A complex
  • cytosol
Biological process
  • cell division
  • cell cycle
  • exit from mitosis
  • peptidyl-serine dephosphorylation
  • mitotic cell cycle
  • developmental process
  • regulation of phosphoprotein phosphatase activity
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

55844

52432

Ensembl

ENSG00000175470

ENSMUSG00000041769

UniProt

Q66LE6

Q925E7

RefSeq (mRNA)

NM_001003656
NM_001291310
NM_018461

NM_026391
NM_001347618

RefSeq (protein)

NP_001278239
NP_060931

NP_001334547
NP_080667

Location (UCSC)Chr 10: 131.9 – 131.96 MbChr 7: 138.85 – 138.88 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

PP2A subunit B isoform delta also known as serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform is a protein that in humans is encoded by the PPP2R2D gene.[5] It is a regulatory subunit of the heterotrimeric protein phosphatase 2 enzyme.

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000175470 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000041769 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: Protein phosphatase 2 regulatory subunit Bdelta".

Further reading

  • Batut J, Schmierer B, Cao J, Raftery LA, Hill CS, Howell M (September 2008). "Two highly related regulatory subunits of PP2A exert opposite effects on TGF-beta/Activin/Nodal signalling". Development. 135 (17): 2927–37. doi:10.1242/dev.020842. PMC 4940033. PMID 18697906.
  • Chen HF, Lin LN, Chen YX, Wan JX, Luo J, Zhang CZ, Li XJ, Hu YM, Mai JR, Chen W, Lin ZN, Lin YC (2012). "Identification and functional analysis of variant haplotypes in the 5'-flanking region of protein phosphatase 2A-Bδ gene". PLOS ONE. 7 (4): e35524. Bibcode:2012PLoSO...735524C. doi:10.1371/journal.pone.0035524. PMC 3335092. PMID 22539979.
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