NEDD1

Protein-coding gene in the species Homo sapiens
NEDD1
Identifiers
AliasesNEDD1, GCP-WD, TUBGCP7, neural precursor cell expressed, developmentally down-regulated 1, NEDD1 gamma-tubulin ring complex targeting factor
External IDsOMIM: 600372; MGI: 97293; HomoloGene: 7439; GeneCards: NEDD1; OMA:NEDD1 - orthologs
Gene location (Human)
Chromosome 12 (human)
Chr.Chromosome 12 (human)[1]
Chromosome 12 (human)
Genomic location for NEDD1
Genomic location for NEDD1
Band12q23.1Start96,907,224 bp[1]
End96,953,780 bp[1]
Gene location (Mouse)
Chromosome 10 (mouse)
Chr.Chromosome 10 (mouse)[2]
Chromosome 10 (mouse)
Genomic location for NEDD1
Genomic location for NEDD1
Band10|10 C2Start92,520,608 bp[2]
End92,558,282 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • secondary oocyte

  • Skeletal muscle tissue of rectus abdominis

  • biceps brachii

  • sperm

  • vastus lateralis muscle

  • deltoid muscle

  • buccal mucosa cell

  • ventricular zone

  • Skeletal muscle tissue of biceps brachii

  • tibialis anterior muscle
Top expressed in
  • zygote

  • secondary oocyte

  • primary oocyte

  • atrium

  • right ventricle

  • cardiac muscles

  • digastric muscle

  • genital tubercle

  • myocardium of ventricle

  • triceps brachii muscle
More reference expression data
BioGPS


More reference expression data
Gene ontology
Molecular function
  • protein binding
Cellular component
  • cytoplasm
  • microtubule organizing center
  • ciliary basal body
  • centriole
  • cytosol
  • centrosome
  • apical part of cell
  • spindle pole
  • pericentriolar material
  • cytoskeleton
Biological process
  • cell division
  • protein localization to centrosome
  • cell cycle
  • G2/M transition of mitotic cell cycle
  • ciliary basal body-plasma membrane docking
  • regulation of G2/M transition of mitotic cell cycle
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

121441

17997

Ensembl

ENSG00000139350

ENSMUSG00000019988

UniProt

Q8NHV4

P33215

RefSeq (mRNA)

NM_001135175
NM_001135176
NM_001135177
NM_152905

NM_008682

RefSeq (protein)

NP_001128647
NP_001128648
NP_001128649
NP_690869

NP_032708

Location (UCSC)Chr 12: 96.91 – 96.95 MbChr 10: 92.52 – 92.56 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Neural precursor cell expressed, developmentally down-regulated 1, also known as Nedd1, is a human gene[5] and encodes the protein NEDD1.

NEDD1 is localized in the centrosome and it plays a role in mitosis through its interaction with γ-tubulin. WD40 repeats are located in the amino-terminal of the protein and are responsible for NEDD1 localization in the centrosome, and the carboxy-terminal amino acids are needed for interactions with γ-tubulin. Depletion of NEDD1 causes impaired centrosome and chromatin microtubules assembly that results in the failure of microtubule nucleation and prevents proper spindle formation.

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000139350 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000019988 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: NEDD1 neural precursor cell expressed, developmentally down-regulated 1".

Further reading

  • Pinyol R, Scrofani J, Vernos I (2012). "The role of NEDD1 phosphorylation by Aurora A in chromosomal microtubule nucleation and spindle function". Curr. Biol. 23 (2): 143–9. doi:10.1016/j.cub.2012.11.046. hdl:10230/23504. PMID 23273898.
  • Sdelci S, Schütz M, Pinyol R, et al. (2012). "Nek9 phosphorylation of NEDD1/GCP-WD contributes to Plk1 control of γ-tubulin recruitment to the mitotic centrosome". Curr. Biol. 22 (16): 1516–23. Bibcode:2012CBio...22.1516S. doi:10.1016/j.cub.2012.06.027. PMID 22818914.
  • Haren L, Remy MH, Bazin I, et al. (2006). "NEDD1-dependent recruitment of the gamma-tubulin ring complex to the centrosome is necessary for centriole duplication and spindle assembly". J. Cell Biol. 172 (4): 505–15. doi:10.1083/jcb.200510028. PMC 2063671. PMID 16461362.
  • Lüders J, Patel UK, Stearns T (2006). "GCP-WD is a gamma-tubulin targeting factor required for centrosomal and chromatin-mediated microtubule nucleation". Nat. Cell Biol. 8 (2): 137–47. doi:10.1038/ncb1349. PMID 16378099. S2CID 27587898.
  • Jung SY, Malovannaya A, Wei J, et al. (2005). "Proteomic analysis of steady-state nuclear hormone receptor coactivator complexes". Mol. Endocrinol. 19 (10): 2451–65. doi:10.1210/me.2004-0476. PMID 16051665. S2CID 24948585.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Takai S, Yoshida Y, Noda M, et al. (1995). "Assignment of the developmentally regulated gene NEDD1 to human chromosome 12q22 by fluorescence in situ hybridization". Hum. Genet. 95 (1): 96–8. doi:10.1007/BF00225082. PMID 7814034. S2CID 902030.


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