FBXW2

Protein-coding gene in the species Homo sapiens
FBXW2
Identifiers
AliasesFBXW2, FBW2, Fwd2, Md6, F-box and WD repeat domain containing 2
External IDsOMIM: 609071; MGI: 1353435; HomoloGene: 8131; GeneCards: FBXW2; OMA:FBXW2 - orthologs
Gene location (Human)
Chromosome 9 (human)
Chr.Chromosome 9 (human)[1]
Chromosome 9 (human)
Genomic location for FBXW2
Genomic location for FBXW2
Band9q33.2Start120,751,978 bp[1]
End120,793,416 bp[1]
Gene location (Mouse)
Chromosome 2 (mouse)
Chr.Chromosome 2 (mouse)[2]
Chromosome 2 (mouse)
Genomic location for FBXW2
Genomic location for FBXW2
Band2|2 BStart34,694,526 bp[2]
End34,716,323 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • buccal mucosa cell

  • mucosa of sigmoid colon

  • vulva

  • trabecular bone

  • skin of hip

  • skin of thigh

  • lower lobe of lung

  • caput epididymis

  • human penis

  • germinal epithelium
Top expressed in
  • dentate gyrus of hippocampal formation granule cell

  • muscle of thigh

  • superior frontal gyrus

  • lumbar spinal ganglion

  • endocardial cushion

  • lip

  • thymus

  • ventricular zone

  • blood

  • neural layer of retina
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • protein binding
  • ubiquitin-protein transferase activity
Cellular component
  • cytosol
Biological process
  • proteolysis
  • protein polyubiquitination
  • post-translational protein modification
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

26190

30050

Ensembl

ENSG00000119402

ENSMUSG00000035949

UniProt

Q9UKT8
Q4VXH1

Q60584

RefSeq (mRNA)

NM_012164
NM_001375888
NM_001375889
NM_001375890

NM_001164768
NM_001164769
NM_001164770
NM_001164772
NM_013890

NM_001379115
NM_001379116
NM_001379117
NM_001379118

RefSeq (protein)

NP_036296
NP_001362817
NP_001362818
NP_001362819

n/a

Location (UCSC)Chr 9: 120.75 – 120.79 MbChr 2: 34.69 – 34.72 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

F-box/WD repeat-containing protein 2 is a protein that in humans is encoded by the FBXW2 gene.[5][6][7]

Function

F-box proteins are an expanding family of eukaryotic proteins characterized by an approximately 40 amino acid motif, the F box. Some F-box proteins have been shown to be critical for the ubiquitin-mediated degradation of cellular regulatory proteins. In fact, F-box proteins are one of the four subunits of ubiquitin protein ligases, called SCFs. SCF ligases bring ubiquitin conjugating enzymes to substrates that are specifically recruited by the different F-box proteins. Mammalian F-box proteins are classified into three groups based on the presence of either WD-40 repeats, leucine-rich repeats, or the presence or absence of other protein-protein interacting domains. This gene encodes the second identified member of the F-box gene family and contains multiple WD-40 repeats.[7]

Interactions

FBXW2 has been shown to interact with SKP1A.[5]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000119402 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000035949 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b Cenciarelli C, Chiaur DS, Guardavaccaro D, Parks W, Vidal M, Pagano M (Dec 1999). "Identification of a family of human F-box proteins". Curr Biol. 9 (20): 1177–9. Bibcode:1999CBio....9.1177C. doi:10.1016/S0960-9822(00)80020-2. PMID 10531035. S2CID 7467493.
  6. ^ Chiaur DS, Murthy S, Cenciarelli C, Parks W, Loda M, Inghirami G, Demetrick D, Pagano M (Jun 2000). "Five human genes encoding F-box proteins: chromosome mapping and analysis in human tumors". Cytogenet Cell Genet. 88 (3–4): 255–8. doi:10.1159/000015532. PMID 10828603. S2CID 431704.
  7. ^ a b "Entrez Gene: FBXW2 F-box and WD repeat domain containing 2".

Further reading

  • Patton EE, Willems AR, Tyers M (1998). "Combinatorial control in ubiquitin-dependent proteolysis: don't Skp the F-box hypothesis". Trends Genet. 14 (6): 236–43. doi:10.1016/S0168-9525(98)01473-5. PMID 9635407.
  • Winston JT, Koepp DM, Zhu C, Elledge SJ, Harper JW (1999). "A family of mammalian F-box proteins". Curr. Biol. 9 (20): 1180–2. Bibcode:1999CBio....9.1180W. doi:10.1016/S0960-9822(00)80021-4. PMID 10531037. S2CID 14341845.
  • Busino L, Donzelli M, Chiesa M, Guardavaccaro D, Ganoth D, Dorrello NV, Hershko A, Pagano M, Draetta GF (2003). "Degradation of Cdc25A by beta-TrCP during S phase and in response to DNA damage". Nature. 426 (6962): 87–91. Bibcode:2003Natur.426...87B. doi:10.1038/nature02082. PMID 14603323. S2CID 768783.
  • Watanabe N, Arai H, Nishihara Y, Taniguchi M, Watanabe N, Hunter T, Osada H (2004). "M-phase kinases induce phospho-dependent ubiquitination of somatic Wee1 by SCFβ-TrCP". Proc. Natl. Acad. Sci. U.S.A. 101 (13): 4419–24. Bibcode:2004PNAS..101.4419W. doi:10.1073/pnas.0307700101. PMC 384762. PMID 15070733.
  • Yang CS, Yu C, Chuang HC, Chang CW, Chang GD, Yao TP, Chen H (2005). "FBW2 targets GCMa to the ubiquitin-proteasome degradation system". J. Biol. Chem. 280 (11): 10083–90. doi:10.1074/jbc.M413986200. PMID 15640526.
  • Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
  • Kimura K, Wakamatsu A, Suzuki Y, Ota T, Nishikawa T, Yamashita R, Yamamoto J, Sekine M, Tsuritani K, Wakaguri H, Ishii S, Sugiyama T, Saito K, Isono Y, Irie R, Kushida N, Yoneyama T, Otsuka R, Kanda K, Yokoi T, Kondo H, Wagatsuma M, Murakawa K, Ishida S, Ishibashi T, Takahashi-Fujii A, Tanase T, Nagai K, Kikuchi H, Nakai K, Isogai T, Sugano S (2006). "Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.


  • v
  • t
  • e