ELP2

Protein-coding gene in the species Homo sapiens
ELP2
Identifiers
AliasesELP2, SHINC-2, STATIP1, StIP, elongator acetyltransferase complex subunit 2, MRT58
External IDsOMIM: 616054; MGI: 1889642; HomoloGene: 6019; GeneCards: ELP2; OMA:ELP2 - orthologs
Gene location (Human)
Chromosome 18 (human)
Chr.Chromosome 18 (human)[1]
Chromosome 18 (human)
Genomic location for ELP2
Genomic location for ELP2
Band18q12.2Start36,129,444 bp[1]
End36,180,557 bp[1]
Gene location (Mouse)
Chromosome 18 (mouse)
Chr.Chromosome 18 (mouse)[2]
Chromosome 18 (mouse)
Genomic location for ELP2
Genomic location for ELP2
Band18|18 A2Start24,735,923 bp[2]
End24,772,564 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • left ovary

  • Achilles tendon

  • right ovary

  • skin of abdomen

  • ganglionic eminence

  • skin of leg

  • epithelium of colon

  • right uterine tube

  • body of pancreas

  • canal of the cervix
Top expressed in
  • saccule

  • otic placode

  • motor neuron

  • facial motor nucleus

  • internal carotid artery

  • condyle

  • external carotid artery

  • primitive streak

  • utricle

  • fossa
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
  • RNA polymerase II complex binding
  • protein kinase binding
Cellular component
  • histone acetyltransferase complex
  • transcription elongation factor complex
  • nucleus
  • cytoplasm
  • cytosol
  • elongator holoenzyme complex
Biological process
  • regulation of transcription by RNA polymerase II
  • transcription elongation from RNA polymerase II promoter
  • regulation of transcription, DNA-templated
  • transcription, DNA-templated
  • regulation of receptor signaling pathway via JAK-STAT
  • tRNA wobble uridine modification
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

55250

58523

Ensembl

ENSG00000134759

ENSMUSG00000024271

UniProt

Q6IA86

Q91WG4

RefSeq (mRNA)
NM_001242875
NM_001242876
NM_001242877
NM_001242878
NM_001242879

NM_018255
NM_001324465
NM_001324466
NM_001324467
NM_001324468
NM_001324469

NM_021448
NM_001360909

RefSeq (protein)
NP_001229804
NP_001229805
NP_001229806
NP_001229807
NP_001229808

NP_001311394
NP_001311395
NP_001311396
NP_001311397
NP_060725

NP_067423
NP_001347838

Location (UCSC)Chr 18: 36.13 – 36.18 MbChr 18: 24.74 – 24.77 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Elongator complex protein 2 is a protein that in humans is encoded by the ELP2 gene.[5][6][7]

Interactions

ELP2 has been shown to interact with STAT3[6] and Janus kinase 1.[6]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000134759 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000024271 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Hawkes NA, Otero G, Winkler GS, Marshall N, Dahmus ME, Krappmann D, Scheidereit C, Thomas CL, Schiavo G, Erdjument-Bromage H, Tempst P, Svejstrup JQ (Jan 2002). "Purification and characterization of the human elongator complex". J Biol Chem. 277 (4): 3047–52. doi:10.1074/jbc.M110445200. PMID 11714725.
  6. ^ a b c Collum RG, Brutsaert S, Lee G, Schindler C (Oct 2000). "A Stat3-interacting protein (StIP1) regulates cytokine signal transduction". Proc Natl Acad Sci U S A. 97 (18): 10120–5. Bibcode:2000PNAS...9710120C. doi:10.1073/pnas.170192197. PMC 27739. PMID 10954736.
  7. ^ "Entrez Gene: STATIP1 signal transducer and activator of transcription 3 interacting protein 1".

Further reading

  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Kim JH, Lane WS, Reinberg D (2002). "Human Elongator facilitates RNA polymerase II transcription through chromatin". Proc. Natl. Acad. Sci. U.S.A. 99 (3): 1241–6. Bibcode:2002PNAS...99.1241K. doi:10.1073/pnas.251672198. PMC 122174. PMID 11818576.
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
  • Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.


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