CIZ1

Protein-coding gene in humans
CIZ1
Identifiers
AliasesCIZ1, LSFR1, NP94, ZNF356, CDKN1A interacting zinc finger protein 1
External IDsOMIM: 611420; MGI: 1920234; HomoloGene: 8112; GeneCards: CIZ1; OMA:CIZ1 - orthologs
Gene location (Human)
Chromosome 9 (human)
Chr.Chromosome 9 (human)[1]
Chromosome 9 (human)
Genomic location for CIZ1
Genomic location for CIZ1
Band9q34.11Start128,161,251 bp[1]
End128,204,383 bp[1]
Gene location (Mouse)
Chromosome 2 (mouse)
Chr.Chromosome 2 (mouse)[2]
Chromosome 2 (mouse)
Genomic location for CIZ1
Genomic location for CIZ1
Band2|2 BStart32,242,339 bp[2]
End32,270,982 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • right hemisphere of cerebellum

  • left ovary

  • right ovary

  • tibial nerve

  • canal of the cervix

  • body of pancreas

  • skin of leg

  • body of uterus

  • skin of abdomen

  • muscle layer of sigmoid colon
Top expressed in
  • genital tubercle

  • neural layer of retina

  • tail of embryo

  • aortic valve

  • yolk sac

  • primary visual cortex

  • ascending aorta

  • ventricular zone

  • muscle of thigh

  • granulocyte
More reference expression data
BioGPS




More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

25792

68379

Ensembl

ENSG00000148337

ENSMUSG00000039205

UniProt

Q9ULV3

n/a

RefSeq (mRNA)
NM_001131015
NM_001131016
NM_001131017
NM_001131018
NM_001257975

NM_001257976
NM_012127

NM_001252534
NM_001252536
NM_001252537
NM_001252538
NM_028412

RefSeq (protein)
NP_001124487
NP_001124488
NP_001124489
NP_001124490
NP_001244904

NP_001244905
NP_036259

n/a

Location (UCSC)Chr 9: 128.16 – 128.2 MbChr 2: 32.24 – 32.27 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Cip1-interacting zinc finger protein is a protein that in humans is encoded by the CIZ1 gene.[5][6]

Function

The protein encoded by this gene is a zinc finger DNA binding transcription factor that interacts with CIP1 (p21 / CDKN1A), part of a complex with cyclin E. The encoded protein may regulate the cellular localization of CIP1.[6]

Clinical significance

An altered circulating form of the Ciz1 protein is synthesized by lung cancer cells, even when they are at a very early stage. Hence detection of this protein variant in blood could be used as a biomarker for early detection of lung cancer.[7]

Ciz1 mutant mice

Aged (18-mo-old) Ciz1-/- mice have increased neuronal DNA double-strand breaks that likely contributed to their loss of neurons and cognitive decline with age.[8] Embryonic fibroblasts from Ciz1-/- mice show abnormal sensitivity to γ-irradiation with persistent DNA breaks, aberrant cell cycle progression and increased apoptosis.[8]

Interactions

CIZ1 has been shown to interact with P21.[5]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000148337 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000039205 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b Mitsui K, Matsumoto A, Ohtsuka S, Ohtsubo M, Yoshimura A (October 1999). "Cloning and characterization of a novel p21(Cip1/Waf1)-interacting zinc finger protein, ciz1". Biochemical and Biophysical Research Communications. 264 (2): 457–64. doi:10.1006/bbrc.1999.1516. PMID 10529385.
  6. ^ a b "Entrez Gene: CIZ1 CDKN1A interacting zinc finger protein 1".
  7. ^ Higgins G, Roper KM, Watson IJ, Blackhall FH, Rom WN, Pass HI, et al. (November 2012). "Variant Ciz1 is a circulating biomarker for early-stage lung cancer". Proceedings of the National Academy of Sciences of the United States of America. 109 (45): E3128-35. doi:10.1073/pnas.1210107109. PMC 3494940. PMID 23074256.
  8. ^ a b Khan MM, Xiao J, Patel D, LeDoux MS (February 2018). "DNA damage and neurodegenerative phenotypes in aged Ciz1 null mice". Neurobiology of Aging. 62: 180–190. doi:10.1016/j.neurobiolaging.2017.10.014. PMC 5877805. PMID 29154038.

External links

Further reading

  • Lukasik A, Uniewicz KA, Kulis M, Kozlowski P (January 2008). "Ciz1, a p21 cip1/Waf1-interacting zinc finger protein and DNA replication factor, is a novel molecular partner for human enhancer of rudimentary homolog". The FEBS Journal. 275 (2): 332–40. doi:10.1111/j.1742-4658.2007.06203.x. PMID 18081865. S2CID 35928583.
  • Rahman F, Ainscough JF, Copeland N, Coverley D (October 2007). "Cancer-associated missplicing of exon 4 influences the subnuclear distribution of the DNA replication factor CIZ1". Human Mutation. 28 (10): 993–1004. doi:10.1002/humu.20550. PMID 17508423. S2CID 34590449.
  • den Hollander P, Rayala SK, Coverley D, Kumar R (November 2006). "Ciz1, a Novel DNA-binding coactivator of the estrogen receptor alpha, confers hypersensitivity to estrogen action". Cancer Research. 66 (22): 11021–9. doi:10.1158/0008-5472.CAN-06-2336. PMID 17108141.
  • Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M (November 2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.
  • Coverley D, Marr J, Ainscough J (January 2005). "Ciz1 promotes mammalian DNA replication". Journal of Cell Science. 118 (Pt 1): 101–12. doi:10.1242/jcs.01599. PMID 15585571.
  • Warder DE, Keherly MJ (2004). "Ciz1, Cip1 interacting zinc finger protein 1 binds the consensus DNA sequence ARYSR(0-2)YYAC". Journal of Biomedical Science. 10 (4): 406–17. doi:10.1159/000071160. PMID 12824700. S2CID 202648843.
  • Gilley J, Fried M (July 1999). "Extensive gene order differences within regions of conserved synteny between the Fugu and human genomes: implications for chromosomal evolution and the cloning of disease genes". Human Molecular Genetics. 8 (7): 1313–20. doi:10.1093/hmg/8.7.1313. PMID 10369878.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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