CIM-0216

CIM-0216
Names
Preferred IUPAC name
2-(3,4-Dihydroquinolin-1(2H)-yl)-N-(5-methyl-1,2-oxazol-3-yl)-2-phenylacetamide
Identifiers
CAS Number
  • 1031496-06-6
3D model (JSmol)
  • Interactive image
ChEMBL
  • ChEMBL4303225
ChemSpider
  • 21960401
PubChem CID
  • 42887770
CompTox Dashboard (EPA)
  • DTXSID501336574 Edit this at Wikidata
InChI
  • InChI=1S/C21H21N3O2/c1-15-14-19(23-26-15)22-21(25)20(17-9-3-2-4-10-17)24-13-7-11-16-8-5-6-12-18(16)24/h2-6,8-10,12,14,20H,7,11,13H2,1H3,(H,22,23,25)
    Key: KSEXDSJYVSEVGF-UHFFFAOYSA-N
  • CC1=CC(=NO1)NC(=O)C(C2=CC=CC=C2)N3CCCC4=CC=CC=C43
Properties
Chemical formula
 C21H21N3O2
Molar mass 347.418 g·mol−1
Hazards
GHS labelling:
Pictograms
 GHS07: Exclamation mark
Warning
Hazard statements
 H302, H315, H319, H335
Precautionary statements
 P261, P264, P270, P271, P280, P301+P312, P302+P352, P304+P340, P305+P351+P338, P312, P321, P330, P332+P313, P337+P313, P362, P403+P233, P405, P501
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
Infobox references
Chemical compound

CIM-0216 is a chemical compound which acts as a potent and selective activator of the TRPM3 calcium channel. It produces nociception and inflammation and is used to study the function of the TRPM3 receptor in these processes.[1][2][3][4]

References

  1. ^ Held K, Kichko T, De Clercq K, Klaassen H, Van Bree R, Vanherck JC, et al. (March 2015). "Activation of TRPM3 by a potent synthetic ligand reveals a role in peptide release". Proceedings of the National Academy of Sciences of the United States of America. 112 (11): E1363-72. doi:10.1073/pnas.1419845112. PMC 4371942. PMID 25733887.
  2. ^ Thiel G, Rubil S, Lesch A, Guethlein LA, Rössler OG (October 2017). "Transient receptor potential TRPM3 channels: Pharmacology, signaling, and biological functions". Pharmacological Research. 124: 92–99. doi:10.1016/j.phrs.2017.07.014. PMID 28720517.
  3. ^ Kelemen B, Lisztes E, Vladár A, Hanyicska M, Almássy J, Oláh A, et al. (April 2020). "Volatile anaesthetics inhibit the thermosensitive nociceptor ion channel transient receptor potential melastatin 3 (TRPM3)". Biochemical Pharmacology. 174: 113826. doi:10.1016/j.bcp.2020.113826. hdl:2437/278831. PMID 31987857.
  4. ^ Vangeel L, Benoit M, Miron Y, Miller PE, De Clercq K, Chaltin P, et al. (June 2020). "Functional expression and pharmacological modulation of TRPM3 in human sensory neurons". British Journal of Pharmacology. 177 (12): 2683–2695. doi:10.1111/bph.14994. PMC 7236075. PMID 31985045.
  • v
  • t
  • e
TRP channel modulators
TRPA
Activators
Blockers
TRPC
Activators
Blockers
TRPM
Activators
Blockers
TRPML
Activators
Blockers
TRPP
Activators
Blockers
TRPV
Activators
Blockers
See also: Receptor/signaling modulators • Ion channel modulators